Results 151 to 160 of about 2,328,855 (357)
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo +9 more
wiley +1 more source
Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats [PDF]
, 2010 A key in understanding the neurobiology of addiction and developing effective pharmacotherapies is revealing drug-induced plasticity that results in heightened relapse susceptibility.
Baker, David A. +5 more
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Neurobiology of Disease, 2014 Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease reflecting degeneration of upper and lower motoneurons (MNs).
Marco Milanese +11 more
doaj
Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract [PDF]
, 1992 SR Glaum, RJ Miller
openalex +1 more source
The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study
Brain and Behavior, Volume 15, Issue 7, July 2025.This study is the first to employed TSMR to investigate the causal relationship between 20 acylcarnitines and neurocognitive outcomes. The findings indicate that lower genetically predicted levels of acetyl‐L‐carnitine and butyrylcarnitine are associated with diminished cognitive performance, underscoring their potential clinical implications in the ...
Sisi Luan +4 more
wiley +1 more source
Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond
Neural Plasticity, 2017 When activated, metabotropic glutamate receptors (mGlus) exert long-lasting changes within the glutamatergic synapses. One mechanism is a tonic effect of downstream signal transduction pathways via sustained activation of mGlu itself.
Geehoon Chung, Sang Jeong Kim
doaj +1 more source
Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons [PDF]
, 1993 Yoshinori Sahara, GL Westbrook
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Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.Serotonin receptors in areas of the emotion regulation network in human and rat brains a comparative autoradiographic study. Our systematic comparative analysis revealed significant differences of 5‐HT1A and 5‐HT2 receptor distributions and of their balance within and across components of the human emotion regulation network and homolog areas in rats ...
Anika Kuckertz +4 more
wiley +1 more source
European Journal of Pain, Volume 29, Issue 6, July 2025.ABSTRACT Background Glutamate, the primary neurotransmitter released by nociceptors, is predominantly synthesised by the enzyme Glutaminase 1 (GLS1). The involvement of GLS1 in pain pathways is well supported, as Gls1 heterozygous mice exhibit altered nociception and GLS1 levels increase in the dorsal root ganglia (DRG) under chronic peripheral ...
Anabel Martínez‐Padilla +4 more
wiley +1 more source