Results 151 to 160 of about 82,701 (299)

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease [PDF]

, 2008
Elvira De Leonibus, Francesca Managò, F. Giordani, F. Petrosino, S. Lopez, Alberto Oliverio, Marianne Amalric, Andrea Mele   +7 more
openalex   +1 more source

International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors [PDF]

, 2020
Karen J. Gregory, Cyril Goudet
openalex   +1 more source

Potential TMS biomarkers for GABAB receptor engagement in alcohol use disorder: A systematic review of existing evidence

Alcohol, Clinical and Experimental Research, Volume 49, Issue 12, Page 2633-2648, December 2025.
This systematic review emphasizes the critical role of GABAB receptors (GABABR) in alcohol use disorder (AUD). While GABABR agonists enhance cortical inhibition, as measured by transcranial magnetic stimulation (TMS)‐based markers, alcohol consumption alters GABABR ‐dependent neurophysiological measures, suggesting GABABR dysfunction plays a key role ...
Chiara Montemitro, Sara Terrezza, Federico Maruottolo, Andrea Costumati, Markus Heilig   +4 more
wiley   +1 more source

Evaluation of glycine treatment for reducing alcohol craving and self‐administration in individuals with alcohol use disorder: A human laboratory trial

Alcohol, Clinical and Experimental Research, Volume 49, Issue 12, Page 2836-2854, December 2025.
This RCT evaluated whether the glycine receptor (GlyR) agonist glycine reduces craving and alcohol intake in individuals with AUD. Despite a preclinical rationale for targeting the GlyR, these parameters were not reduced. Interestingly, glycine weakened the link between alcohol‐induced craving and self‐administration, and baseline glycine levels were ...
Yasmin Olsson, Helga Lidö, Mia Ericson, Bo Söderpalm   +3 more
wiley   +1 more source

Epigenetic Alterations in Prenatal Stress Mice as an Endophenotype Model for Schizophrenia: Role of Metabotropic Glutamate 2/3 Receptors [PDF]

, 2018
Francesco Matrisciano, Erbo Dong, Ferdinando Nicoletti, Alessandro Guidotti   +3 more
openalex   +1 more source

Photoswitchable allosteric modulators for metabotropic glutamate receptors

, 2022
Xavier Gómez‐Santacana, Silvia Panarello, Xavier Rovira, Amadeu Llebaria   +3 more
openalex   +1 more source

Methcathinone Neurotoxicity in the Rat Prefrontal Cortex by Integrated Synaptic Changes and Transcriptome Analysis

Addiction Biology, Volume 30, Issue 12, December 2025.
Integrating behavioural, ultrastructural and transcriptomic analyses, this study reveals that subchronic methcathinone exposure damages prefrontal synaptic architecture and alters neuroplasticity‐related gene networks, providing mechanistic insight into its neurotoxic and cognition‐impairing effects.
Rukui Zhou, Yingwen Xu, Chunming Xu, zhe Chen, Jieping Lv, Keming Yun, Zhiwen Wei   +6 more
wiley   +1 more source

Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes

, 2013
Sulochana Devi, Yogananda S. Markandeya, Nityanand Maddodi, Anuradha Dhingra, Noga Vardi, Ravi C. Balijepalli, Vijayasaradhi Setaluri   +6 more
openalex   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source