Results 151 to 160 of about 2,386,092 (307)
Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation
Small Science, Volume 6, Issue 1, January 2026.Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen +10 more
wiley +1 more source
Elevated glycogen synthase kinase 3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential [PDF]
, 2007 Significant advances have been made in understanding the underlying defects of and developing potential treatments for Fragile X Syndrome (FXS), the most common heritable mental retardation.
Bauchwitz, Dr. Robert P.
core
Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.The current work tested the hypothesis that sex differences in alcohol's effects are mediated by astrocytes. Using immunohistochemistry, qRT‐PCR, and ELISAs, we found that nondependent, binge‐like alcohol‐induced increases in hippocampal astrocyte density were more robust in females.
Candace Swepson +6 more
wiley +1 more source
3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1
, 2007 Y. Nataraja Sekhar +4 more
openalex +1 more source
Reduction of Glutamatergic Neurotransmission by Prolonged Exposure to Dieldrin Involves NMDA Receptor Internalization and Metabotropic Glutamate Receptor 5 Downregulation [PDF]
, 2009 Víctor Briz +2 more
openalex +1 more source
British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source
D4 Dopamine and Metabotropic Glutamate Receptors in Cerebral Cortex and Striatum in Rat Brain [PDF]
, 2001 María Alejandra Berger +3 more
openalex +1 more source
European Journal of Neuroscience, Volume 63, Issue 2, January 2026.We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in climbing fiber (CF) to Purkinje cell (PC) synapse elimination during postnatal development of the mouse cerebellum. We performed PC‐specific deletion of FNDC3B by RNAi‐mediated knockdown or PC‐specific conditional knockout in mice and examined CF to PC synapse development
Céline Louise Mercier +13 more
wiley +1 more source
Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas +2 more
wiley +1 more source