Results 181 to 190 of about 2,328,855 (357)

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus [PDF]

, 1996
Domenico E. Pellegrini‐Giampietro, Serenella Albani Torregrossa, Flavio Moroni   +2 more
openalex   +1 more source

Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence

Proceedings of the National Academy of Sciences of the United States of America, 2017
Sophie E. Holmes, M. Girgenti, Margaret T. Davis, R. Pietrzak, Nicole DellaGioia, N. Nabulsi, D. Matuskey, S. Southwick, R. Duman, R. Carson, J. Krystal, I. Esterlis   +11 more
semanticscholar   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Ca2+-Dependent Induction of Intracellular Ca2+ Oscillation in Hippocampal Astrocytes During Metabotropic Glutamate Receptor Activation

Journal of Pharmacological Sciences, 2005
We have investigated whether the intracellular calcium concentration ([Ca2+]i) oscillations induced in astrocytes using the metabotropic glutamate-receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) are Ca2+-dependent, using ...
Yoshitoku Yoshida, Remi Tsuchiya, Nagisa Matsumoto, Mitsuhiro Morita, Hiroyoshi Miyakawa, Yoshihisa Kudo   +5 more
doaj  

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

, 1991
Jae‐Young Koh, Elizabeth E. Palmer, CW Cotman   +2 more
openalex   +1 more source

Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG [PDF]

, 1995
Gernot Riedel, G. Casabona, KG Reymann
openalex   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

Cell Reports, 2019
Summary: Activation of postsynaptic metabotropic glutamate receptors (mGluRs) modulates neuronal excitability and synaptic plasticity, while deregulation of mGluR signaling has been implicated in neurodevelopmental disorders. Overstimulation of mGluRs is
Nicky Scheefhals, Lisa A.E. Catsburg, Margriet L. Westerveld, Thomas A. Blanpied, Casper C. Hoogenraad, Harold D. MacGillavry   +5 more
doaj  

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj