Results 11 to 20 of about 39,446 (289)

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

MicroRNA binding site variation is enriched in psychiatric disorders

Human Mutation, Volume 43, Issue 12, Page 2153-2169, December 2022., 2022
Abstract Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences.
Michael P. Geaghan, William R. Reay, Murray J. Cairns   +2 more
wiley   +1 more source

Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes Grm8a and Grm8b Display Distinct Behavioral Phenotypes in Zebrafish Larvae (Danio rerio)

Frontiers in Molecular Neuroscience, 2022
Members of the family of metabotropic glutamate receptors are involved in the pathomechanism of several disorders of the nervous system. Besides the well-investigated function of dysfunctional glutamate receptor signaling in neurodegenerative diseases ...
Teresa M. Lüffe, Moritz Bauer, Zoi Gioga, Duru Özbay, Marcel Romanos, Christina Lillesaar, Carsten Drepper   +6 more
doaj   +1 more source

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]

, 2012
Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core   +1 more source

Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Differential alteration of synaptic versus extrasynaptic NMDARs in P301S mice. Reduced density of synaptic NMDARs in excitatory synapses in the hippocampus of P301S mice at 10 months. NMDARs at excitatory synapses established on pyramidal cell spines and interneurons are significantly reduced in the CA1 region of the hippocampus compared to age‐matched
Rocío Alfaro‐Ruiz, Carolina Aguado, Alejandro Martín‐Belmonte, Ana Esther Moreno‐Martínez, Jesús Merchán‐Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Luján   +8 more
wiley   +1 more source

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +5 more sources

The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Abstract Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology.
Afia B. Ali, Anam Islam, Andrew Constanti   +2 more
wiley   +1 more source

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
core   +2 more sources

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.

PLoS ONE, 2012
Astrocytes synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide (ODN) an endogenous ligand of both central-type benzodiazepine (CBR) and metabotropic receptors.
Yosra Hamdi, Hadhemi Kaddour, David Vaudry, Seyma Bahdoudi, Salma Douiri, Jérôme Leprince, Helene Castel, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouki   +10 more
doaj   +1 more source