Results 31 to 40 of about 76,012 (229)

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]

, 2015
Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA, FAZIO, FRANCESCO, Lionetto, L, MARTELLETTI, Paolo, Mitsikostas, Dd   +4 more
core   +1 more source

Anti-mGluR1 encephalitis: Case illustration and systematic review

Frontiers in Neurology, 2023
BackgroundThe literature for immune-mediated neurological disorders is evolving like no other field of neurological illnesses. Many new antibodies or disorders have been described in the last decade.
Osama Khojah, Osama Khojah, Osama Khojah, Seraj Makkawi, Seraj Makkawi, Seraj Makkawi, Saeed Alghamdi   +6 more
doaj   +1 more source

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators

Frontiers in Molecular Biosciences, 2022
Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical CBRs CB1 and CB2 are highly implicated in these pathological events.
Paula Morales, Chanté Muller, Nadine Jagerovic, Patricia H. Reggio   +3 more
doaj   +1 more source

Cerebellar encephalitis associated with anti-mGluR1 antibodies: a case report and comprehensive literature review

Frontiers in Neurology
Anti-metabotropic glutamate receptor 1 encephalitis is an uncommon autoimmune condition characterized by a subacute onset of cerebellar syndrome. Frequently, it also manifests as sleep disorders and cognitive or behavioral changes. While immunotherapy is
Xue Chen, Yanan Chen, Lu Di, Na Liu, Ting Liu, Yun Cai, Weiying Di   +6 more
doaj   +1 more source

Causative Factors for ADHD: Role of Copy Number Variants in ADHD

Pediatric Neurology Briefs, 2014
Investigators from Brazil determined if copy number variants (CNVs) in glutamate metabotropic receptor genes (GRM) were overrepresented in 1038 individuals with ADHD compared to 1057 subjects without ADHD.
J Gordon Millichap, John J Millichap
doaj   +1 more source

β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

Life Science Alliance, 2022
GPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule ...
Jung-AA Woo, Yan Yan, Teresa R Kee, Sara Cazzaro, Kyle C McGill Percy, Xinming Wang, Tian Liu, Stephen B Liggett, David E Kang   +8 more
doaj   +1 more source

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]

, 2019
The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Abba, Martín Carlos, Aldaz, Claudio Marcelo, Attaluri, Sahithi, Hattiangady, Bharathi, Hussain, Tabish, Kil, Hyunsuk, Kodali, Maheedhar, Lee, Jaeho, Shen, Jianjun, Shetty, Ashok K., Shuai, Bing, Takata, Yoko   +11 more
core   +2 more sources

Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate–Receptor Blockade

Journal of Pharmacological Sciences, 2008
The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi, Azusa Mikami, Kenichi Shimada, Chiaki Kamei   +3 more
doaj   +1 more source

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Molecules, 2023
Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR1a, mGluR5, or mGluR8.
Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale   +3 more
doaj   +1 more source

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources