Results 191 to 200 of about 2,328,855 (357)

Activation of a metabotropic glutamate receptor increases intracellular calcium concentrations in neurons of the avian cochlear nucleus [PDF]

, 1995
Lance Zirpel, E. A. Lachica, EW Rubel
openalex   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

(2S,1’R, 2'R, 3'R)-2-(2,3-Dicarboxycyclopropyl)-glycine (DCG-IV): A type-specific agonist for metabotropic glutamate receptor negatively coupled with adenylate cyclase in rat hippocampus.

, 1994
Mutsumi Maruyama, Mariko Nakazawa
openalex   +1 more source

Metabotropic glutamate receptors in spatial and nonspatial learning in rats studied by means of agonist and antagonist application. [PDF]

, 1995
Gernot Riedel, Wolfram Wetzel, Klaus G. Reymann   +2 more
openalex   +1 more source

Metabotropic glutamate receptor type 1 autoimmunity

Neurology, 2016
A. S. Lopez-Chiriboga, L. Komorowski, T. Kümpfel, C. Probst, Shannon R. Hinson, S. Pittock, A. McKeon   +6 more
semanticscholar   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer

Nature Communications
Metabotropic glutamate (mGlu) receptor protomers can heterodimerize, leading to different pharmacology compared to their homodimeric counterparts. Here, we use complemented donor-acceptor resonance energy transfer (CODA-RET) technology that distinguishes
Xin Lin, Davide Provasi, Colleen M. Niswender, Wesley B. Asher, Jonathan A. Javitch   +4 more
doaj   +1 more source

Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p. [PDF]

BMC Cancer, 2019
Xiao B, Chen D, Zhou Q, Hang J, Zhang W, Kuang Z, Sun Z, Li L.   +7 more
europepmc   +1 more source

Anticonvulsant action of metabotropic glutamate receptor agonists in DBA/2 mice.

, 1994
Yoshiko Horikawa, Shigeki Tamura, Norio Inomata, Tomochika Ohno   +3 more
openalex   +1 more source