Results 41 to 50 of about 39,446 (289)

Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]

EMBO J 22, 18 (15/09/2003) 4656-65, 2007
Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv   +1 more source

Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]

, 2018
The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A., Gereau, Robert W, McIlvried, Lisa V, Pullen, Melanie Y, Sheahan, Tayler D, Valtcheva, Manouela V   +5 more
core   +2 more sources

Kinetic fingerprinting of metabotropic glutamate receptors

Communications Biology, 2023
AbstractDimeric metabotropic glutamate receptors (mGluRs) are abundantly expressed in neurons. In mammals, eight subunit isoforms, mGluR1-8, have been identified, forming the groups I, II, and III. We investigated receptor dimerization and kinetics of these mGluR isoforms in excised membrane patches by FRET and confocal patch-clamp fluorometry. We show
Taulant Kukaj, Christian Sattler, Thomas Zimmer, Ralf Schmauder, Klaus Benndorf   +4 more
openaire   +3 more sources

Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit

European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022
Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Antonio Malgaroli   +3 more
wiley   +1 more source

Orthogonal Activation of Metabotropic Glutamate Receptor Using Coordination Chemogenetics

Frontiers in Chemistry, 2022
Cell-surface receptors play a pivotal role as transducers of extracellular input. Although different cell types express the same receptor, the physiological roles of the receptor are highly dependent on cell type.
Akinobu Senoo, Yutaro Yamada, Kento Ojima, Kento Ojima, Tomohiro Doura, Itaru Hamachi, Itaru Hamachi, Shigeki Kiyonaka   +7 more
doaj   +1 more source

Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]

arXiv, 2023
Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv  

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Causative Factors for ADHD: Role of Copy Number Variants in ADHD

Pediatric Neurology Briefs, 2014
Investigators from Brazil determined if copy number variants (CNVs) in glutamate metabotropic receptor genes (GRM) were overrepresented in 1038 individuals with ADHD compared to 1057 subjects without ADHD.
J Gordon Millichap, John J Millichap
doaj   +1 more source

The Role of Glutamate Receptors in Epilepsy

Biomedicines, 2023
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen, Tzu-Hsin Huang, Ming-Chi Lai, Chin-Wei Huang   +3 more
doaj   +1 more source

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Molecules, 2023
Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR1a, mGluR5, or mGluR8.
Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale   +3 more
doaj   +1 more source