Results 51 to 60 of about 39,446 (289)

Large number of receptors may reduce cellular response time variation [PDF]

Physical biology 10 (3), 035008, 2013, 2012
Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv   +1 more source

Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]

, 2017
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K., Jong, Yuh-Jiin I., Kumar, Vikas, O\u27Malley, Karen L., Sergin, Ismail   +4 more
core   +2 more sources

Cerebellar encephalitis associated with anti-mGluR1 antibodies: a case report and comprehensive literature review

Frontiers in Neurology
Anti-metabotropic glutamate receptor 1 encephalitis is an uncommon autoimmune condition characterized by a subacute onset of cerebellar syndrome. Frequently, it also manifests as sleep disorders and cognitive or behavioral changes. While immunotherapy is
Xue Chen, Yanan Chen, Lu Di, Na Liu, Ting Liu, Yun Cai, Weiying Di   +6 more
doaj   +1 more source

Ionotropic and metabotropic responses by alpha 7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of cys-loop receptors characterized by the assembly of five subunits into a multi-protein channel complex.
Patricia Sinclair, Nadine Kabbani
doaj  

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. [PDF]

, 2015
Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial ...
BATTAGLIA, Giuseppe, CRUCCU, Giorgio, DI STEFANO, GIULIA, E. Pasquale, LATTANZI, Roberta, NICOLETTI, Ferdinando, PIROSO, SERENA, S. Notartomaso, TRUINI, ANDREA   +8 more
core   +1 more source

mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine [PDF]

, 2012
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine.
arxiv   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]

, 2010
Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa, Chai, Minqiang, Crombag, Hans, Engblom, David, Halbout, Briac, Novak, Martin, O'Connor, Eoin, Parkitna, Jan Rodriguez, Schütz, Günther, Spanagel, Rainer, Stephens, David N, Su, Tian   +11 more
core   +2 more sources

Cardiac mGluR1 metabotropic receptors in cardioprotection [PDF]

Cardiovascular Research, 2017
In a previous study using a genome-wide microarray strategy, we identified metabotropic glutamate receptor 1 (mGluR1) as a putative cardioprotective candidate in ischaemic postconditioning (PostC). In the present study, we investigated the role of cardiac mGluR1 receptors during cardioprotection against myocardial ischaemia-reperfusion injury in the ...
Vincent, Anne, Sportouch, Catherine, Covinhes, Aurélie, Barrère, Christian, Gallot, Laura, Delgado-Betancourt, Viviana, Lattuca, Benoît, Solecki, Kamila, Boisguérin, Prisca, Piot, Christophe, Nargeot, Joël, Barrère-Lemaire, Stéphanie   +11 more
openaire   +3 more sources