Results 41 to 50 of about 733,097 (288)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Maximizing Metadata: Embedded Metadata Tools [PDF]

open access: yes, 2018
Archives, libraries, museums, businesses, and individuals have fully embraced the digital era and the proliferation of digital assets abound. The challenge is creating, managing, storing, and sharing these assets. One way to make managing your digital files easier is by using the power of embedded metadata, which encodes data about the digital asset ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Publishing trends of journals with manuscripts in PubMed Central: changes from 2008–2009 to 2015–2016

open access: yesJournal of the Medical Library Association, 2018
Objective: The National Institutes of Health (NIH) public access policy mandates that all articles containing NIH-funded research must be deposited into PubMed Central (PMC). The aim of this study was to assess publishing trends of journals that were not
Lauren Topper, Diane Boehr
doaj   +1 more source

Optimising metadata workflows in a distributed information environment [PDF]

open access: yes, 2005
The different purposes present within a distributed information environment create the potential for repositories to enhance their metadata by capitalising on the diversity of metadata available for any given object.
Barton, Jane, Robertson, R. John
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Sustaining Collection Value: Managing Collection/Item Metadata Relationships [PDF]

open access: yes, 2008
Many aspects of managing collection/item metadata relationships are critical to sustaining collection value over time. Metadata at the collection-level not only provides context for finding, understanding, and using the items in the collection, but is ...
Dubin, David   +4 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A Metadata Registry for Metadata Interoperability

open access: yesData Science Journal, 2007
In order to use distributed and heterogeneous scientific databases effectively, semantic heterogeneities have to be detected and resolved. To solve this problem, we propose architecture for managing metadata and metadata schema using a metadata registry.
Jian-hui Li   +4 more
doaj   +1 more source

Preparing LIS Students for a Career in Metadata Librarianship [PDF]

open access: yes, 2014
This study examines the field of metadata librarianship and its emergence from the field of traditional MARC cataloging. Through a survey distributed to academic librarians, public librarians, digital librarians, special librarians, corporate librarians,
Mooney Gonzales, Brighid
core   +1 more source

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