Results 51 to 60 of about 288,519 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Free-Text Collection-Level Subject Metadata in Large-Scale Digital Libraries: A Comparative Content Analysis [PDF]
, 2011 This paper reports results of the study that used an in-depth comparative content analysis to assess free-text collection-level subject metadata in three large-scale digital cultural heritage aggregations in the United States and ...
Zavalina, Oksana L., Zavalina, Oksana
core
Journal of the Medical Library Association, 2018 Objective: The National Institutes of Health (NIH) public access policy mandates that all articles containing NIH-funded research must be deposited into PubMed Central (PMC). The aim of this study was to assess publishing trends of journals that were not
Lauren Topper, Diane Boehr
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
A Dublin Core Application Profile in the Agricultural Domain [PDF]
, 2001 This report outlines a proposed metadata framework for resource discovery of agricultural resources, and in particular to describe information resources in agricultural sciences.
Katz, Stephen +2 more
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Experiments in Operationalizing Metadata Quality Interfaces: A Case Study at the University of North Texas Libraries [PDF]
, 2018 Paper presented at the 2018 International Conference on Dublin Core and Metadata Applications Initiative (DCMI). This paper describes work underway at the University of North Texas (UNT) Libraries to design and implement interfaces and tools for ...
Tarver, Hannah, Phillips, Mark Edward
core
Provenance Description of Metadata Vocabularies for the Long-term Maintenance of Metadata
Journal of Data and Information Science, 2017 The purpose of this paper is to discuss provenance description of metadata terms and metadata vocabularies as a set of metadata terms. Provenance is crucial information to keep track of changes of metadata terms and metadata vocabularies for their ...
Li Chunqiu, Sugimoto Shigeo
doaj +1 more source
A Metadata Prefetching Strategy Based on Provenance Information [PDF]
Jisuanji gongcheng, 2016 In distributed file systems,metadata prefetching can reduce the response latency of metadata server.Existing metadata prefetching strategies prefetch metadata according to its past file access pattern,without considering the correlations between process ...
WU Guojin,HU Cheng
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source