Results 141 to 150 of about 7,625,042 (246)

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Pithos - a scalable and secure data container for FAIR-compliant research data management in life sciences. [PDF]

J Integr Bioinform
Schlegel J, Beyvers S, Hansen M, Brehm L, Goesmann A, Förster F.   +5 more
europepmc   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

The need for standardization and improved open (meta)data practices in metaproteomics. [PDF]

Microbiome
Van Den Bossche T, Wolf M, Armengaud J, Arntzen MØ, Benndorf D, Figeys D, Grenga L, Hettich RL, John NS, Jagtap P, Jehmlich N, Kleiner M, Kunath BJ, Li L, Lipton M, Mesuere B, Neely BA, Ning Z, Pedersen AL, Perez-Riverol Y, Rajan J, Schallert K, Seifert J, Uzzau S, Verschaffelt P, Wilmes P, Vizcaíno JA, Martens L, Heyer R.   +28 more
europepmc   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

Bridging TG-116 and TG-232: A retrospective multi-vendor evaluation of deviation index re-centering and process control in digital radiography. [PDF]

J Appl Clin Med Phys
AbuAzzah E, Alrehily F, Gameraddin M, Alshoabi S, Alsharif W, Alsultan KD, Alshamrani A, Al-Radadi K, Badawy R, Al-Jabri S, Al-Harbi T, Al-Hazme N.   +11 more
europepmc   +1 more source

SNIRF2BIDS: a GUI-based tool for converting functional near-infrared spectroscopy data to the Brain Imaging Data Structure in R. [PDF]

Neurophotonics
Lorenz-de Laigue R, Svaldi J, Schroeder PA.   +2 more
europepmc   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Re-curating a 90-year ecological data collection from an Australian arid zone enclosure according to FAIR principles. [PDF]

Sci Data
Specht A, Fittock M, Karsdorp W, Singh Ramesh A, Sanchez Gonzalez J, Guru SM.   +5 more
europepmc   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source