Results 41 to 50 of about 60,710 (308)

Enriching e-learning metadata through digital library usage analysis [PDF]

, 2007
Peer-reviewedIn this paper we propose an evaluation framework for analyzing learning objects usage, with the aim of extracting useful information for improving the quality of the metadata used to describe the learning objects, but also for ...
Casadesús Brugués, Jaume, Minguillón, Julià, Ferran Ferrer, Núria, Krakowska, Monika, Ferran-Ferrer, Núria, Minguillón Alfonso, Julià, Casadesús, Jaume, Ferran, Núria   +7 more
core   +1 more source

Graph-based Analysis and Visualization of Metadata in the Context of Urban Digital Twins [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Urban Digital Twins (UDT) depend on integrating various heterogeneous data sources to represent complex urban environments. Metadata management is an essential component of such systems.
M. Knezevic, F. Fuchsloch, A. Donaubauer, T. H. Kolbe   +3 more
doaj   +1 more source

Navigating the Landscape: A Comprehensive Review of Current Virus Databases

Viruses, 2023
Viruses are abundant and diverse entities that have important roles in public health, ecology, and agriculture. The identification and surveillance of viruses rely on an understanding of their genome organization, sequences, and replication strategy ...
Muriel Ritsch, Noriko A. Cassman, Shahram Saghaei, Manja Marz   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Building Quality Assurance into Metadata Creation: an Analysis based on the Learning Objects and e-Prints Communities of Practice [PDF]

, 2003
This paper challenges some of the assumptions underlying the metadata creation process in the context of two communities of practice, based around learning object repositories and open e-Print archives.
Hey, Jessie M. N., Currier, Sarah, Barton, Jane, Hey, Jessie M.N., Hey, J.M.N., Barton, J., Currier, S.   +6 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Experiences in deploying metadata analysis tools for institutional repositories

, 2009
Current institutional repository software provides few tools to help metadata librarians understand and analyze their collections. In this article, we compare and contrast metadata analysis tools that were developed simultaneously, but independently, at ...
Paynter, Gordon W., Blandford, Ann, Twidale, MB, Nichols, David M., Bainbridge, David, McKay, Dana, McKay, D, Chan, Chu-Hsiang, Paynter, GW, Nichols, DM, Chan, CH, Blandford, A, Twidale, Michael B., Bainbridge, D   +13 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Metadata tools for institutional repositories [PDF]

, 2008
Current institutional repository software provides few tools to help metadata librarians understand and analyse their collections. In this paper we compare and contrast metadata analysis tools that were developed simultaneously, but independently, at two
Chan, Chu-Hsiang, Paynter, Gordon W., Blandford, Ann, Nichols, David M., Bainbridge, David, McKay, Dana, Twidale, Michael B.   +6 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source