Results 51 to 60 of about 266,079 (291)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Evaluating Descriptive Richness in Collection-Level Metadata

open access: yesJournal of Library Metadata, 2009
ABSTRACT When many collections are 1 brought together in a federation or aggregation, the attributes of the original collections can become difficult to discern. Collection-level 2 metadata has the potential to provide important context about the purpose and features of individual collections, but the qualitative aspects of collections are difficult to
Zavalina, Oksana L.   +3 more
openaire   +2 more sources

A Robust Fault-Tolerant and Scalable Cluster-wide Deduplication for Shared-Nothing Storage Systems

open access: yes, 2018
Deduplication has been largely employed in distributed storage systems to improve space efficiency. Traditional deduplication research ignores the design specifications of shared-nothing distributed storage systems such as no central metadata bottleneck,
Hamandawana, Prince   +4 more
core   +1 more source

Secure, performance-oriented data management for nanoCMOS electronics [PDF]

open access: yes, 2008
The EPSRC pilot project Meeting the Design Challenges of nanoCMOS Electronics (nanoCMOS) is focused upon delivering a production level e-Infrastructure to meet the challenges facing the semiconductor industry in dealing with the next generation of ...
Asenov, A.   +10 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

ISO 19115 for GeoWeb services orchestration

open access: yesGeoinformatics FCE CTU, 2009
The paper describes theoretical and practical possibilities of ISO 19115 standard in a process of generating dynamic GeoWeb services orchestras. There are several ways how to instantiate orchestras according to current state of services and user needs ...
Jan Růžička
doaj   +1 more source

A preliminary evaluation of metadata records machine translation [PDF]

open access: yesThe Electronic Library, 2012
PurposeThe purpose of this study is to evaluate freely available machine translation (MT) services' performance in translating metadata records.Design/methodology/approachRandomly selected metadata records were translated from English into Chinese using Google, Bing, and SYSTRAN MT systems.
Chen, Jiangping   +3 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Ranking Archived Documents for Structured Queries on Semantic Layers

open access: yes, 2018
Archived collections of documents (like newspaper and web archives) serve as important information sources in a variety of disciplines, including Digital Humanities, Historical Science, and Journalism.
Arikan Irem   +8 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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