Results 71 to 80 of about 64,067 (293)

Schema Playground: a tool for authoring, extending, and using metadata schemas to improve FAIRness of biomedical data

BMC Bioinformatics, 2023
Background Biomedical researchers are strongly encouraged to make their research outputs more Findable, Accessible, Interoperable, and Reusable (FAIR). While many biomedical research outputs are more readily accessible through open data efforts, finding ...
Marco A. Cano, Ginger Tsueng, Xinghua Zhou, Jiwen Xin, Laura D. Hughes, Julia L. Mullen, Andrew I. Su, Chunlei Wu   +7 more
doaj   +1 more source

Defining a metadata schema for serious games as learning objects [PDF]

, 2012
Games are increasingly recognized for their educational potential. However, when used as a learning resource, games can differ substantially from other educational media. They often combine high-fidelity audio and video content with experiential, social,
Arnab, Sylvester, de Freitas, Sara, Dunwell, Ian, Hendrix, Maurice, LLanas, J., Petridis, Panagiotis, Protopsaltis, Aristidis, Rolland, C.   +7 more
core   +2 more sources

Assessing Descriptive Substance in Free-Text Collection-Level Metadata [PDF]

, 2008
Collection-level metadata has the potential to provide important information about the features and purpose of individual collections. This paper reports on a content analysis of collection records in an aggregation of cultural heritage collections.
Han, Myung-Ja K., Jackson, Amy S., Palmer, Carole L., Zavalina, Oksana L.   +3 more
core   +3 more sources

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Format-independent media delivery, applied to RTP, MP4, and Ogg [PDF]

, 2010
The current multimedia landscape is characterized by a significant heterogeneity in terms of coding and delivery formats, usage environments, and user preferences. This paper introduces a transparent multimedia content adaptation and delivery approach, i.
Debevere, Pedro, Van de Walle, Rik, Van Deursen, Davy, Van Lancker, Wim   +3 more
core   +2 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Development of a metadata schema describing Institutional Repository content objects enhanced by ''LODE-BD'' strategies

JLIS.it, 2013
Based on ''Guidelines for metadata creation and management in the Institutional Repositories'' (CRUI, Italy, 2012) and ''LODE-BD Recommendations'' (AIMS, 2012), and exploring other principles and strategies for qualitative development of metadata ...
Iryna Solodovnik
doaj   +6 more sources

The matter of meta in research data management: Introducing the CESSDA Metadata Office Project

IASSIST Quarterly, 2020
Accompanying the growing importance of research data management, the provision and maintenance of metadata – understood as data about (research) data – have obtained a key role in contextualizing, understanding, and preserving research data ...
André Förster, Kerrin Borschewski, Sharon Bolton, Taina Jääskeläinen   +3 more
doaj   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source