Results 131 to 140 of about 43,311 (300)

Using the OpenURL framework to locate bibliographic resources [PDF]

open access: yes, 2003
OpenURLs are already in use in digital library information services providing links between resources that are appropriate to the context of the end-user.
MacIntyre, Ross, Apps, Ann
core  

Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design

open access: yesAdvanced Science, EarlyView.
A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram   +4 more
wiley   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu   +20 more
wiley   +1 more source

Towards a sound management of digital culture. Metadata schemes and application profiles for digital repositories [PDF]

open access: yes, 2010
If we give a look to the present panorama of digital research – particularly if applied to cultural heritage collections - we have to admit that there is still more attention to the quality of data than to the necessary series of management activities ...
Feliciati, Pierluigi
core  

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai   +12 more
wiley   +1 more source

Metadata Standards Directory [PDF]

open access: yes, 2016
The Research Data Alliance Metadata Standards Directory Working Group (MSDWG) ran from August 2013 to March 2015, with the aim of building a directory to promote the discovery, access and use of metadata standards relevant for research data. The work was conducted in three stages. First, the group examined existing metadata standard discovery tools and
openaire  

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan   +11 more
wiley   +1 more source

Memex Metadata (M2) for Reflective Learning [PDF]

open access: yes, 2006
This paper reports on metadata research and development supporting memory and reflective learning that is being conducted as part of the Memex Metadata (M2) for Student Portfolios project, University of North Carolina at Chapel Hill.
Oberlin, John   +2 more
core  

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

open access: yesAdvanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang   +8 more
wiley   +1 more source

Integrating Machine Learning Standards in Disseminating Machine Learning Research

open access: yesData Science Journal
The increasing use of AI-based approaches such as machine learning (ML) across diverse scientific fields presents challenges for reproducibly disseminating and assessing research.
Scott C. Edmunds   +6 more
doaj   +1 more source

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