Results 211 to 220 of about 82,780 (305)

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Water kefir as a paradigm for multi-omics and genome-scale metabolic modelling in fermented food. [PDF]

NPJ Biofilms Microbiomes
Khan A, Breselge S, O'Mahony AK, O'Sullivan O, Cotter PD, McCarthy SN, Mahony J, Kenny JG.   +7 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis. [PDF]

Nat Microbiol
Treichel NS, Pauvert C, Séneca J, Pjevac P, Berry D, Penders J, Hitch TCA, Clavel T.   +7 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Omics-Guided Construction of Microbial Consortia for Reproducible Traditional Fermented Foods and Beverages. [PDF]

Foods
Song D, Yang L, Zhang C.
europepmc   +1 more source

Improved library preparation for Ion Torrent sequencing using custom-made Y-adapters

, 2019
Forth, Leonie
core  

Washed Microbiota Transplantation Improves Chronic‐Phase Febrile Infection‐Related Epilepsy Syndrome: The First Case Report With Long‐Term Follow‐Up and Integrated Multi‐Omics Analysis

Microbiota Medicine Research, EarlyView.
ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy. Survivors often enter a chronic phase characterized by drug‐resistant epilepsy, cognitive impairment, behavioral and psychiatric symptoms, and long‐term functional disability.
Qianqian Li, Xiao Ding, Sheng Zhang, Faming Zhang   +3 more
wiley   +1 more source

Library preparation strategy critically impacts RNA virus sensitivity in clinical metagenomics

Stepniak D, Constantinides B, Weaver M, Treagus S, Wilkinson SA, Quarton S, Behruznia M, Cumley N, Tyson J, McNally A, Loman NJ, Pullan S, Quick J.   +12 more
europepmc   +1 more source

Diagnostic sensitivity and specificity of metagenomic sequencing and qPCR for detection of viruses associated with bovine respiratory disease estimated using Bayesian latent class models. [PDF]

Front Vet Sci
Donbraye E, McLeod L, Chai Z, Lacoste SR, McCarthy EL, Hill JE, Erickson NEN, Links MG, Otto SJG, Huang Y, Waldner CL.   +10 more
europepmc   +1 more source