Results 211 to 220 of about 91,219 (305)

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Integrating multi-omics technologies to decipher microbiome functions. [PDF]

Nat Commun
Van Den Bossche T, Lazau EA, Aho VTE, Alfredo Blakeley-Ruiz J, Wolf M, Kunath BJ, Valentin-Alvarado LE, Hellwig P, Verschaffelt P, Rajczewski AT, Henderickx JGE, Suomi T, Xian F, Shah S, Martens L, Benndorf D, Damare SR, Haak BW, Haange SB, Piehowski PD, Kupczok A, Figeys D, Mesuere B, Palmblad M, Hettich RL, Elo LL, Vizcaíno JA, Garg N, Wang Z, Arıkan M, McCue LA, Griffin TJ, Clerbaux LA, Heyer R, Medema MH, Matallana-Surget S, Gomez-Varela D, Muth T, Tillett B, Armengaud J, Finn RD, Wilmes P, Gregory Caporaso J, Grenga L, Jagtap PD.   +44 more
europepmc   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Syndromic cholera diagnosis masks diverse causes of diarrhoeal disease in Burundi revealed by portable metagenomics. [PDF]

PLoS Negl Trop Dis
Egholm Bruun Jensen E, Nzoyikorera N, Ivanova M, Leekitcharoenphon P, Noelle Uwineza M, Diawara I, Nyandwi J, M Aarestrup F, Otani S.   +8 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Computational Genomics for Resistome Characterization: Current Advancements and Future Challenges Under a One Health Perspective. [PDF]

Antibiotics (Basel)
García Gutiérrez L, Méndez-Tenorio A, López-Luis MÁ, Ávila-Huerta SA, León-Ávila G, Castaño-Valencia SR, Ibáñez-Cervantes G.   +6 more
europepmc   +1 more source

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

Interdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang, Baoyuan Zhu, Yuanyuan Huang, Liqin Liang, Zhaobo Li, Yunheng Diao, Minxin Guo, Heng Zhang, Jing Zhou, Fengchun Wu, Kai Wu   +10 more
wiley   +1 more source

Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025. [PDF]

One Health
Udahemuka JC, Cassidy H, Schuele L, Uwibambe E, Ngabo MG, Masirika LM, Sindayiheba R, Otani S, Gashegu M, Twizere JC, Aarestrup F, Ndayisenga F, Oude Munnink BB, Koopmans MPG, Ndishimye P.   +14 more
europepmc   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Optimizing a culture-enriched hybrid metagenomics pipeline to assess the AMR footprint of livestock manure in anaerobic digestate. [PDF]

Microbiol Spectr
Rahman N, Rahman ASMZ, Levin DB, McAllister TA, Cicek N, Derakhshani H.   +5 more
europepmc   +1 more source