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Monitoring the microbiome for food safety and quality using deep shotgun sequencing

open access: yesnpj Science of Food, 2021
In this work, we hypothesized that shifts in the food microbiome can be used as an indicator of unexpected contaminants or environmental changes. To test this hypothesis, we sequenced the total RNA of 31 high protein powder (HPP) samples of poultry meal ...
Kristen L. Beck   +21 more
doaj   +1 more source

Epitachophoresis is a novel versatile total nucleic acid extraction method

open access: yesScientific Reports, 2021
Epitachophoresis is a novel next generation extraction system capable of isolating DNA and RNA simultaneously from clinically relevant samples. Here we build on the versatility of Epitachophoresis by extracting diverse nucleic acids ranging in lengths ...
Vladimira Datinska   +8 more
doaj   +1 more source

Truvari: refined structural variant comparison preserves allelic diversity

open access: yesGenome Biology, 2022
The fundamental challenge of multi-sample structural variant (SV) analysis such as merging and benchmarking is identifying when two SVs are the same.
Adam C. English   +4 more
doaj   +1 more source

Unraveling the salt tolerance of Phi29 DNA polymerase using compartmentalized self-replication and microfluidics platform

open access: yesFrontiers in Microbiology, 2023
In Phi29-α–hemolysin (α-HL) nanopore sequencing systems, a strong electrochemical signal is dependent on a high concentration of salt. However, high salt concentrations adversely affect polymerase activity.
Yaping Sun   +10 more
doaj   +1 more source

Tournament Sequences and Meeussen Sequences [PDF]

open access: yesThe Electronic Journal of Combinatorics, 2000
A tournament sequence is an increasing sequence of positive integers $(t_1,t_2,\ldots)$ such that $t_1=1$ and $t_{i+1} \leq 2t_i$. A Meeussen sequence is an increasing sequence of positive integers $(m_1,m_2,\ldots)$ such that $m_1=1$, every nonnegative integer is the sum of a subset of the $\{m_i\}$, and each integer $m_i-1$ is the sum of a unique ...
Cook, Matthew, Kleber, Michael
openaire   +5 more sources

Grounded Sequence to Sequence Transduction

open access: yesIEEE Journal of Selected Topics in Signal Processing, 2020
Speech recognition and machine translation have made major progress over the past decades, providing practical systems to map one language sequence to another. Although multiple modalities such as sound and video are becoming increasingly available, the state-of-the-art systems are inherently unimodal, in the sense that they take a single modality ...
Lucia Specia   +17 more
openaire   +3 more sources

Unusual sequence characteristics of human chromosome 19 are conserved across 11 nonhuman primates

open access: yesBMC Evolutionary Biology, 2020
Background Human chromosome 19 has many unique characteristics including gene density more than double the genome-wide average and 20 large tandemly clustered gene families.
R. Alan Harris   +3 more
doaj   +1 more source

PRINCESS: comprehensive detection of haplotype resolved SNVs, SVs, and methylation

open access: yesGenome Biology, 2021
Long-read sequencing has been shown to have advantages in structural variation (SV) detection and methylation calling. Many studies focus either on SV, methylation, or phasing of SNV; however, only the combination of variants provides a comprehensive ...
Medhat Mahmoud   +3 more
doaj   +1 more source

Recognizing Sequences of Sequences

open access: yesPLoS Computational Biology, 2009
The brain's decoding of fast sensory streams is currently impossible to emulate, even approximately, with artificial agents. For example, robust speech recognition is relatively easy for humans but exceptionally difficult for artificial speech recognition systems.
Stefan J. Kiebel   +3 more
openaire   +7 more sources

Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation

open access: yesGenome Biology, 2023
Background Systematic characterization of how  genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits.
Jun Wang   +10 more
doaj   +1 more source

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