Results 41 to 50 of about 3,190,493 (303)

Novel characterization discoveries of ferroptosis-associated molecules in COAD microenvironment based TCGA data

open access: yesFrontiers in Molecular Biosciences, 2022
Background and Objective: One of the most recent forms of programmed cell death, ferroptosis, is crucial in tumorigenesis. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system’s ...
Salem Baldi   +11 more
doaj   +1 more source

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer. [PDF]

open access: yes, 2019
Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care.
Carpten, John D   +4 more
core   +3 more sources

High-throughput Quant-iT PicoGreen assay using an automated liquid handling system

open access: yesBioTechniques, 2019
Workflows in NGS facilities require high-standard practices and high-throughput pipelines to process the large number of samples received in a timely manner. Downstream protocols such as NGS library preparation require accurate estimation of nucleic acid
Kay Anantanawat   +3 more
doaj   +1 more source

Whole-genome sequencing and the clinician: a tale of two cities [PDF]

open access: yes, 2014
Clinicians are faced with unprecedented opportunities to identify the genetic aetiologies of hitherto molecularly uncharacterised conditions via the use of high-throughput sequencing.
A. R. Foley   +21 more
core   +2 more sources

Comparison of SARS-CoV-2 sequencing using the ONT GridION and the Illumina MiSeq

open access: yesBMC Genomics, 2022
Background Over 4 million SARS-CoV-2 genomes have been sequenced globally in the past 2 years. This has been crucial in elucidating transmission chains within communities, the development of new diagnostic methods, vaccines, and antivirals.
Derek Tshiabuila   +12 more
doaj   +1 more source

Webteaching: sequencing of subject matter in relation to prior knowledge of pupils [PDF]

open access: yes, 1983
Two experiments are discussed in which the sequencing procedure of webteaching is compared with a linear sequence for the presentation of text material.\ud \ud In the first experiment variations in the level of prior knowledge of pupils were studied for ...
B. Hayes-Roth   +16 more
core   +2 more sources

Genomic targets for high-resolution inference of kinship, ancestry and disease susceptibility in orang-utans (genus: Pongo)

open access: yesBMC Genomics, 2020
Background Orang-utans comprise three critically endangered species endemic to the islands of Borneo and Sumatra. Though whole-genome sequencing has recently accelerated our understanding of their evolutionary history, the costs of implementing routine ...
Graham L. Banes   +8 more
doaj   +1 more source

Chimeric Phi29 DNA polymerase with helix–hairpin–helix motifs shows enhanced salt tolerance and replication performance

open access: yesMicrobial Biotechnology, 2021
Summary Phi29 DNA polymerase (Phi29 Pol) has been successfully applied in DNA nanoball‐based sequencing, real‐time DNA sequencing from single polymerase molecules and nanopore sequencing employing the sequencing by synthesis (SBS) method.
Yaping Gao   +6 more
doaj   +1 more source

Biological and technical factors in the assessment of blood-based tumor mutational burden (bTMB) in patients with NSCLC

open access: yesJournal for ImmunoTherapy of Cancer, 2022
Background Patients treated with immunotherapy are at risk of considerable adverse events, and the ongoing struggle is to accurately identify the subset of patients who will benefit.
Kim Monkhorst   +9 more
doaj   +1 more source

Analysis and Kinetics of the Sequencing Batch Reactors [PDF]

open access: yes, 2007
Fundamental analysis and kinetics of treatment reactors are major topics in environmental engineering literature. These fundamental topics in reactor processes are well known for the ideal batch reactor, the continuous stirred tank reactor, and the plug ...
Ndon, Udeme J
core   +2 more sources

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