Results 61 to 70 of about 910,209 (262)
BARCOSEL: a tool for selecting an optimal barcode set for high-throughput sequencing
BMC Bioinformatics, 2018 Background Current high-throughput sequencing platforms provide capacity to sequence multiple samples in parallel. Different samples are labeled by attaching a short sample specific nucleotide sequence, barcode, to each DNA molecule prior pooling them ...
Panu Somervuo +5 more
doaj +1 more source
Deconstructing the Polymerase Chain Reaction II: an improved workflow and effects on artifact formation and primer degeneracy [PDF]
PeerJ, 2019 Polymerase chain reaction (PCR) amplification of complex microbial genomic DNA templates with degenerate primers can lead to distortion of the underlying community structure due to inefficient primer-template interactions leading to bias.
Ankur Naqib +2 more
doaj +2 more sources
Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant
Life Science Alliance, 2021 This study uses DNA sequencing to trace a donor organ transplant–mediated cancer transmission and illustrates how precise molecular pathology profiles might reduce future risk for transplant recipients.
Marie-Claude Gingras +15 more
doaj +1 more source
Convolutional Sequence to Sequence Learning
CoRR, 2017 The prevalent approach to sequence to sequence learning maps an input sequence to a variable length output sequence via recurrent neural networks. We introduce an architecture based entirely on convolutional neural networks. Compared to recurrent models, computations over all elements can be fully parallelized during training and optimization is easier
Jonas Gehring +4 more
openaire +4 more sources
estMOI: estimating multiplicity of infection using parasite deep sequencing data. [PDF]
, 2014 Individuals living in endemic areas generally harbour multiple parasite strains. Multiplicity of infection (MOI) can be an indicator of immune status and transmission intensity.
Sutherland, Colin J +5 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
npj MicrogravityThe surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health.
Aparna Krishnavajhala +17 more
doaj +1 more source
Efficient Method for Molecular Characterization of the 5′ and 3′ Ends of the Dengue Virus Genome
Viruses, 2020 Dengue is a mosquito-borne disease that is of major importance in public health. Although it has been extensively studied at the molecular level, sequencing of the 5′ and 3′ ends of the untranslated regions (UTR) commonly requires specific approaches for
Alicia Rosales-Munar +4 more
doaj +1 more source
Assessing Incrementality in Sequence-to-Sequence Models [PDF]
Proceedings of the 4th Workshop on Representation Learning for NLP (RepL4NLP-2019), 2019 Since their inception, encoder-decoder models have successfully been applied to a wide array of problems in computational linguistics. The most recent successes are predominantly due to the use of different variations of attention mechanisms, but their cognitive plausibility is questionable.
Ulmer, D., Hupkes, D., Bruni, E.
openaire +5 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source