Results 81 to 90 of about 2,613,419 (309)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
ParMap, an Algorithm for the Identification of Complex Genomic Variations in Nextgen Sequencing Data [PDF]
, 2010 Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especially, small insertions and deletions.
Raul Rabadan +4 more
core
Beatty sequences and Langford sequences
Discrete Mathematics, 1993 A disjoint covering system (DCS) of Beatty sequences is the collection of Beatty sequences \((\alpha_ i,\beta_ i)=\{\lfloor n_ i+ n_ i\rfloor: n\in{\mathbb{Z}}^ +\}\) with \(\alpha_ i>0\), \(\beta_ i\) real numbers, which partition \(\mathbb{Z}^ +\).
Roger B. Eggleton +2 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
On the Balancedness of Relaxed Sequencing Games [PDF]
This paper shows that some classes of relaxed sequencing games, which arise from the class of sequencing games as introduced in Curiel, Pederzoli, Tijs (1989), are balanced.sequencing situations;sequencing games;balancedness;game ...
Velzen, S. van, Hamers, H.J.M.
core
$A$-sequences, $Z$-sequence, and $B$-sequences of Riordan Matrices
Discret. Math., 2019 We defined two type $B$-sequences of Riordan arrays and present the $A$-sequence characterization and $Z$-sequence characterization of the Riordan matrices with two type $B$-sequences. The subgroups characterized by $A$-sequences and $Z$-sequences are studied.
openaire +4 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Batch Sequencing and Cooperation [PDF]
Game theoretic analysis of sequencing situations has been restricted to manufactur- ing systems which consist of machines that can process only one job at a time.
Borm, P.E.M. +3 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source