Results 81 to 90 of about 2,098,916 (269)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Batch Sequencing and Cooperation
Game theoretic analysis of sequencing situations has been restricted to manufactur- ing systems which consist of machines that can process only one job at a time.
Borm, P.E.M. +3 more
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Sequence ‘minimization’: exploring the sequence landscape with simplified sequences
Current Opinion in Biotechnology, 1995 The challenges of protein engineering arise, in part, from the enormous number of possible sequences and the almost unimaginably small fraction of such sequences that can be studied experimentally or computationally. Fortunately, not all possibilities need to be considered because many different sequences can adopt the same structure.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Partitioning Sequencing Situations and Games
The research that studies the interaction between sequencing situations and cooperative games, that started with the paper of Curiel et al. (1989), has become an established line of research.
Gerichhausen, M., Hamers, H.J.M.
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
On the Balancedness of Relaxed Sequencing Games
This paper shows that some classes of relaxed sequencing games, which arise from the class of sequencing games as introduced in Curiel, Pederzoli, Tijs (1989), are balanced.sequencing situations;sequencing games;balancedness;game ...
Velzen, S. van, Hamers, H.J.M.
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, 2016 Genotyping-by-sequencing: Emerging alternative technology to array based genotyping for GBLUP & GWAS. Two “categories” - oligo directed re-sequencing of specific regions -targeted; reduced representational re-sequencing- restriction enzyme digests ...
Ken Dodds (3501542) +3 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Sequencing Games with Controllable Processing Time
In this paper we study a class of cooperative sequencing games that arise from sequencing situations in which the processing times are not fixed.We show that these games are balanced by obtaining two core elements that depend only on the optimal schedule
Velzen, S. van
core