Results 51 to 60 of about 91,219 (305)

Pattern-Recognition Receptors and Cervical Microbiome in Patients with Early Miscarriages

International Journal of Inflammation
Early miscarriages are one of the main causes of reproductive losses. The objective of this study was to estimate Toll- and NOD-like receptors mRNA expression levels and their correlation with microbiome composition in the endocervix of patients with 1st
Mariya V. Gryaznova, Olesya N. Kozarenko, Victoria M. Ivannikova, Yuliya D. Smirnova, Inna Y. Burakova, Oxana B. Altukhova, Natalia I. Samborskaya, Mikhail Y. Syromyatnikov, Alexander Y. Maslov, Olga P. Lebedeva   +9 more
doaj   +1 more source

Maximal viral information recovery from sequence data using VirMAP

Nature Communications, 2018
Viral taxonomic characterization from metagenomic data suffers from high background noise and signal crosstalk. Here, the authors develop VirMAP, a novel pipeline for analyses of metagenomic data that classifies viral reconstructions independent of ...
Nadim J Ajami, Matthew C. Wong, Matthew C. Ross, Richard E. Lloyd, Joseph F. Petrosino   +4 more
doaj   +1 more source

Investigating Colonization of the Healthy Adult Gastrointestinal Tract by Fungi

mSphere, 2018
A wide diversity of fungi have been detected in the human gastrointestinal (GI) tract with the potential to provide or influence important functions. However, many of the fungi most commonly detected in stool samples are also present in food or the oral ...
Thomas A. Auchtung, Tatiana Y. Fofanova, Christopher J. Stewart, Andrea K. Nash, Matthew C. Wong, Jonathan R. Gesell, Jennifer M. Auchtung, Nadim J. Ajami, Joseph F. Petrosino   +8 more
doaj   +1 more source

Metagenomics in Virology

, 2021
Metagenomics, i.e., the sequencing and analysis of genomic information extracted directly from clinical or environmental samples, has become a fundamental tool to explore the viral world. Against the background of an extensive viral diversity revealed by
Matthijnssens, Jelle, Jelle Matthijnssens, Dutilh, Bas E, Simon Roux, Bas E. Dutilh, Roux, Simon   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An overlooked phenomenon: complex interactions of potential error sources on the quality of bacterial de novo genome assemblies

BMC Genomics
Background Parameters adversely affecting the contiguity and accuracy of the assemblies from Illumina next-generation sequencing (NGS) are well described.
Zoltán Rádai, Alex Váradi, Péter Takács, Nikoletta Andrea Nagy, Nicholas Schmitt, Eszter Prépost, Gábor Kardos, Levente Laczkó   +7 more
doaj   +1 more source

Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes

Environmental Microbiome, 2019
Background Yamuna, a major tributary of Ganga, which flows through the national capital region of Delhi, is among the major polluted rivers in India. The accumulation of various effluents, toxic chemicals, heavy metals, and increased organic load in the ...
Parul Mittal, Vishnu Prasoodanan PK, Darshan B. Dhakan, Sanjiv Kumar, Vineet K. Sharma   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Hydrogen cyanide in the rhizosphere: not suppressing plant pathogens, but rather regulating availability of phosphate

Frontiers in Microbiology, 2016
Plant growth promoting rhizobacteria produce chemical compounds with different benefits for the plant. Among them, HCN is recognized as a biocontrol agent, based on its ascribed toxicity against plant pathogens.
Tomaž Rijavec, Tomaž Rijavec, Aleš Lapanje, Aleš Lapanje, Aleš Lapanje   +4 more
doaj   +1 more source

Introduction to Computational Metagenomics [PDF]

, 2022
Breakthroughs in high-throughput genome sequencing and high-performance computing technologies have empowered scientists to decode many genomes including our own.
Zhong Wang, Wang, Zhong
core   +1 more source