Results 51 to 60 of about 540,123 (267)

METAL FREE PROSTHODONTICS

annals and essences of dentistry, 2011
Metal free or All –ceramic restorations are the term for restorations consisting solely of ceramics without any metal support. They are highly esthetic.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Covalent Organic Frameworks with Molecular Electronic Modulation as Metal‐Free Electrocatalysts for Efficient Hydrogen Peroxide Production

Small Structures, 2023
Tuning the electronic property of active center to balance the adsorption ability and reactivity of oxygen is essential for achieving 2e− oxygen reduction reaction (ORR) for electrocatalytic synthesis of hydrogen peroxide (H2O2), still represents a grand
Shaoda Huang, Shuanglong Lu, Yiming Hu, Yongyong Cao, Yang Li, Fang Duan, Han Zhu, Yinghua Jin, Mingliang Du, Wei Zhang   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metal‐Free Intermolecular Aminoarylation of Alkynes

Angewandte Chemie, 2017
AbstractA metal‐free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides.
Pauline T. G. Rabet, Scott Boyd, Michael F. Greaney   +2 more
openaire   +4 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

DABCO- and DBU-promoted one-pot reaction of N-sulfonyl ketimines with Morita–Baylis–Hillman carbonates: a sequential approach to (2-hydroxyaryl)nicotinate derivatives

Beilstein Journal of Organic Chemistry, 2018
An intriguing DABCO-catalyzed and DBU-promoted one-pot synthesis of an important class of (2-hydroxyaryl)pyridine derivatives bearing a carboxylate or a nitrile group suitably placed at C3 position of the aza-ring has been achieved in acceptable chemical
Soumitra Guin, Raman Gupta, Debashis Majee, Sampak Samanta   +3 more
doaj   +1 more source

Sustainable, Oxidative, and Metal‐Free Annulation

Chemistry – A European Journal, 2017
AbstractAnnulation has received steadily growing interest in the interplay with the increasing emphasis towards selective C−H bond functionalization reactions. Metal‐free oxidative annulation through functionalization of inert and abundant C−H bonds offers great improvements in terms of atom‐ and step‐economics as well as reduced waste production under
Luis Bering, Srimanta Manna, Andrey P. Antonchick   +2 more
openaire   +4 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones

Molecules
The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple and practical method for the synthesis of amide-containing quinazolin-4(3H)-
Jia-Jun Tang, Meng-Yang Zhao, Ying-Jun Lin, Li-Hua Yang, Long-Yong Xie   +4 more
doaj   +1 more source