Results 61 to 70 of about 540,123 (267)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines

ChemistryOpen, 2022
Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment.
Haiying Tian, Ruiyan Li, Dr. Fang Guo, Dr. Xiuling Chen   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Dual-Mechanism Study of Metal-Free g-C₃N₄ Catalysts for Advanced Oxidation Under Non-Photocatalytic Conditions

Molecules
Metal-free materials have been proved to be promising replacements of traditional metal-based catalysts for advanced oxidation reactions. Carbon nitride was found to be able to activate H2O2 and generate hydroxyl radicals (•OH).
Zixu Yang, Yang Sun, Weizhi Wang, Xiaohan Yuan, Pengfei Tian, Jing Xu   +5 more
doaj   +1 more source

Metal-free aerobic oxidations mediated by N-hydroxyphthalimide. A concise review

Beilstein Journal of Organic Chemistry, 2013
Since the beginning of the century, N-hydroxyphthalimide and related compounds have been revealed to be efficient organocatalysts for free-radical processes and have found ample application in promoting the aerobic oxidation of a wide range of organic ...
Lucio Melone, Carlo Punta
doaj   +1 more source

Clarifying the Origin of Oxygen Reduction Activity in Heteroatom-Modified Defective Carbon

Cell Reports Physical Science, 2020
Summary: Metal-free oxygen reduction reaction (ORR) catalysts have been intensively studied during the past decade. For heteroatom-modified carbon materials, the influence of heteroatoms on the ORR remains unclear.
Xuecheng Yan, Hongli Liu, Yi Jia, Longzhou Zhang, Wenjia Xu, Xin Wang, Jun Chen, Dongjiang Yang, Xiangdong Yao   +8 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Development of Metal-Free Porous Organic Polymers for Sustainable Carbon Dioxide Photoreduction

Nanomaterials
A viable tactic to effectively address the climate crisis is the production of renewable fuels via photocatalytic reactions using solar energy and available resources like carbon dioxide (CO2) and water.
Ranjit Bariki, Reshma G. Joseph, Oussama M. El-Kadri, Mohammad H. Al-Sayah   +3 more
doaj   +1 more source