Results 41 to 50 of about 2,024,283 (321)

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Digital Light Processing of 2D Lattice Composites for Tunable Self‐Sensing and Mechanical Performance

open access: yesAdvanced Engineering Materials, EarlyView., 2023
The study presents the mechanical and in situ sensing performance of digital light processing‐enabled 2D lattice nanocomposites under monotonic tensile and repeated cyclic loading, and provides guidelines for the design of architectures suitable for strain sensors and smart lightweight structures.
Omar Waqas Saadi   +3 more
wiley   +1 more source

Beyond the Toolpath: Site-Specific Melt Pool Size Control Enables Printing of Extra-Toolpath Geometry in Laser Wire-Based Directed Energy Deposition

open access: yesApplied Sciences, 2019
A variety of techniques have been utilized in metal additive manufacturing (AM) for melt pool size management, including modeling and feed-forward approaches. In a few cases, closed-loop control has been demonstrated.
Brian T. Gibson   +3 more
doaj   +1 more source

Analysis of Materials and Modern Technologies for PDC Drill Bit Manufacturing

open access: yesУспехи физики металлов, 2020
The article presents a review of polycrystalline diamond composite (PDC) drill bit manufacturing technologies and used metals in order to provide surface quality and accuracy as well as to attract a wider range of scientists to find new technologies and ...
L. Ya. Ropyak, T. O. Pryhorovska, K. H. Levchuk
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Creep Characterization of Inconel 718 Lattice Metamaterials Manufactured by Laser Powder Bed Fusion

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, the creep characteristics of additively manufactured Inconel 718 metamaterials are investigated. The creep behavior of metamaterials and the effects of microstructural defects are assessed, and the microstructure defects are accurately captured using Kachanov's creep damage model.
Akash Singh Bhuwal   +5 more
wiley   +1 more source

Mycorrhizal effectiveness and manganese toxicity in soybean as affected by soil type and endophyte

open access: yesScientia Agricola, 2003
Mycorrhizal plants may present Mn toxicity alleviation and this depends on the plant-endophyte-environment interaction. The effectiveness of three arbuscular mycorrhizal fungi (AMF) (Glomus macrocarpum, G. etunicatum, G.
Marco Antonio Nogueira   +1 more
doaj  

Total phenolic, flavonoids and some selected metal content in honey and propolis samples from South Wolo zone, Amhara region, Ethiopia

open access: yesCogent Food & Agriculture, 2018
Ethiopia is endowed with a variety of multifloral origin of honey and propolis. However, there is paucity of information on the chemical composition of honey and propolis for some of the regions.
Tesfaye Liben   +2 more
doaj   +1 more source

Characterization of Acinetobacter baumannii Copper Resistance Reveals a Role in Virulence

open access: yesFrontiers in Microbiology, 2020
Acinetobacter baumannii is often highly drug-resistant and causes severe infections in compromised patients. These infections can be life threatening due to limited treatment options.
Caitlin L. Williams   +9 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

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