Results 51 to 60 of about 2,343,514 (318)

Assessing the material loss of the modular taper interface in retrieved metal on metal hip replacements [PDF]

, 2015
Measuring the amount of material loss in the case of revised hip replacements is considered to be a prerequisite of understanding and assessing the true in vivo performance of the implant.
Racasan, R., Bills, Paul J., Blunt, Liam, Tessier, P, Tessier, P., Blunt, L. A., Racasan, Radu   +6 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Therapeutic functions of medical implants from various material categories with integrated biomacromolecular systems

Frontiers in Bioengineering and Biotechnology
Medical implants are designed to replace missing parts or improve body functions and must be capable of providing structural support or therapeutic intervention for a medical condition.
Guilherme Bedeschi Calais, Guilherme Domingos Garcia, Celso Fidelis de Moura Júnior, José Diego Magalhães Soares, José Diego Magalhães Soares, Liliane Maria Ferrareso Lona, Marisa Masumi Beppu, Jacobo Hernandez-Montelongo, Jacobo Hernandez-Montelongo, João Batista Maia Rocha Neto   +9 more
doaj   +1 more source

Metal–Metal Bonding

, 2013
This chapter deals with the electronic structure of metal-metal bonds in molecular systems, a diverse topic that now spans almost the entire periodic table. The field is most often associated with strong multiple bonds such as the iconic quadruple bond in [Re2Cl8]2-, and the recently discovered ultra-short Cr-Cr quintuple bonds provide a remarkable ...
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Female, Mosher, Transgressor: A 'Moshography' of Transgressive Practices within the Leeds Extreme Metal Scene [PDF]

, 2014
This paper examines and reconceptualises transgression in the Leeds extreme metal music subculture through theories of performance, embodiment and spectacle. The spectacle, for Debord (1967), is a social relation that is alienating and mediated by images,
Spracklen, K, Riches, G, Lashua, B
core   +1 more source

Metal w cieniu kwitnącej wiśni. Specyfika i przemiany gatunku na gruncie japońskim

Annales Universitatis Paedagogicae Cracoviensis. Studia de Cultura, 2018
W niniejszym artykule autorka zarysowuje cechy charakterystyczne japońskiego metaluw kolejnych dekadach jego rozwoju, co następuje poprzez przedstawienie twórczościwybranych zespołów, działalności fanów oraz wskazanie źródeł inspiracji artystów ...
Agnieszka Kiejziewicz
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source