Results 101 to 110 of about 2,133,478 (281)

Phenotypic and molecular consequences of overexpression of metal-homeostasis genes [PDF]

, 2014
Metal hyperaccumulating plants are able to store very large amounts of metals in their shoots. There are a number of reasons why it is important to be able to introduce metal hyperaccumulation traits into nonaccumulating species (e.g., phytoremediation ...
Anna Barabasz, Anna eBarabasz, Danuta Maria eAntosiewicz, Oskar eSiemianowski, Danuta M. Antosiewicz, Oskar Siemianowski   +5 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

A flow equilibrium model controlling cytoplasmic transition metal cation pools and preventing mis-metalation as exemplified for zinc homeostasis

Journal of Bacteriology
The metal cations of the first transition period fill up their 3d orbitals from 3d5 for Mn(II) to 3d10 for Zn(II). Enzymes use these cations as cofactors and exploit their individual chemical features for important catalytic reactions. A prerequisite for
Dietrich H. Nies
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

From Metal Stress to Regulated Cell Death: An Evidence Framework for Ferroptosis–Cuproptosis Crosstalk in Cancer

Cells
Resistance to apoptosis, metabolic plasticity, and redox adaptation are major contributors to cancer progression and treatment failure. Ferroptosis and cuproptosis have therefore emerged as metal-dependent forms of regulated cell-death programs with ...
Andrada-Adelaida Belbe, Lorin-Manuel Pîrlog, Andrei Sporiș, Adela-Diana Pitforodeschi, Alissia-Nicoleta Pilatec, Rareș-Mihai Băilă, Irina Rusu, Mihaela Amelia Dobrescu, Mariela-Sanda Militaru, Irina-Ioana Iordănescu, Andreea Cătană   +10 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications

Frontiers in Cell and Developmental Biology
Cuproptosis is a regulated form of cell death triggered by copper overload and dependent on mitochondrial metabolism, particularly through FDX1-mediated protein lipoylation and TCA cycle disruption. Recent studies have revealed that epigenetic mechanisms,
Xin Zhang, Yixiao Yuan, Lin Tang, Juan Wang, Lincan Duan, Xiulin Jiang, Jia Zhang   +6 more
doaj   +1 more source

Sheet Metal Workers' International Association charter

, 1994
Sheet Metal Workers' International Association charter, local union #146, Springfield, Missouri. Legible names on the document include Charles G. Gibson, Gary L. Comer, Randy L. Smith, J. Michael Dailey, David V. Maples, William W. Newlon Jr., Donald L.
Sheet Metal Workers' International Association
core  

Seramik- Metal Soğuk Birleştirmeler Ve Performanslarının İncelenmesi [PDF]

, 2007
06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması ...
Yardımcı Doçent Doktor Ramazan Kayıkçı ; Yrd. Doç. Dr. Ali Osman Kurt, Sakarya Üniversitesi, Fen Bilimleri Enstitüsü, Metal Eğitimi Anabilim Dalı, Metal Eğitimi, Ünal, İbrahim   +2 more
core  

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source