Results 81 to 90 of about 2,133,478 (281)

Bridging the Gap to Non-toxic Fungal Control: Lupinus-Derived Blad-Containing Oligomer as a Novel Candidate to Combat Human Pathogenic Fungi

Frontiers in Microbiology, 2017
The lack of antifungal drugs with novel modes of action reaching the clinic is a serious concern. Recently a novel antifungal protein referred to as Blad-containing oligomer (BCO) has received regulatory approval as an agricultural antifungal agent ...
Ana M. Pinheiro, Alexandra Carreira, Thomas A. K. Prescott, Ricardo B. Ferreira, Sara A. Monteiro, Sara A. Monteiro   +5 more
doaj   +1 more source

Altered Expression of ZnT10 in Alzheimer's Disease Brain [PDF]

, 2013
There is an increasing body of evidence suggesting that metal homeostasis is dysregulated in the pathology of Alzheimer's disease (AD). Although expression levels of several transporters belonging the SLC30 family, which comprises predominantly zinc ...
Ruth A. Valentine (208371), Paul A Adlard, Ruth A. Valentine, Helen J. Bosomworth (417547), Ford, D, Bosomworth, Helen, Adlard, Paul, Dianne Ford, Valentine, Ruth, Paul A. Adlard, Paul A. Adlard (31148), Dianne Ford (174115), Bosomworth, HJ, Helen J Bosomworth, Ruth A Valentine, Skoulakis, Efthimios, Helen J. Bosomworth, Adlard, PA, Valentine, RA, Ford, Dianne   +19 more
core   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

Advanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà, Giulia Cazzador, Roberta Fabbri, Matteo Calosi, Alessandro Silvestri, Andrea Candini, Fabiola Liscio, Franco Corticelli, Aikaterini Konstantoulaki, Andrea D'Iorio, Marco Caprini, Vincenzo Palermo, Monica Bertoldo, Valentina Benfenati, Chiara Zanardi, Emanuele Treossi   +15 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Comparative analyses of phytochelatin synthase (PCS) genes in higher plants

Biotechnology & Biotechnological Equipment, 2019
Plants employ various defence strategies to ameliorate the effects of heavy metal exposures, leading to re-establishment of metal homeostasis. One of the strategies includes the biosynthesis of main heavy metal detoxifying peptides phytochelatins (PCs ...
Ertugrul Filiz, Ibrahim Adnan Saracoglu, Ibrahim Ilker Ozyigit, Bahattin Yalcin   +3 more
doaj   +1 more source

Copper and Zinc Homeostasis: Lessons from Drosophila melanogaster

Frontiers in Genetics, 2017
Maintenance of metal homeostasis is crucial for many different enzymatic activities and in turn for cell function and survival. In addition, cells display detoxification and protective mechanisms against toxic accumulation of metals.
Juan A. Navarro, Stephan Schneuwly
doaj   +1 more source

General Aspects of Metal Ions as Signaling Agents in Health and Disease

Biomolecules, 2020
This review focuses on the current knowledge on the involvement of metal ions in signaling processes within the cell, in both physiological and pathological conditions.
Karolina Krzywoszyńska, Danuta Witkowska, Jolanta Świątek-Kozłowska, Agnieszka Szebesczyk, Henryk Kozłowski   +4 more
doaj   +1 more source

Altered transition metal homeostasis in Niemann-Pick disease, type C1 [PDF]

, 2014
The loss of NPC1 protein function is the predominant cause of Niemann-Pick type C1 disease (NP-C1), a systemic and neurodegenerative disorder characterized by late-endosomal/lysosomal accumulation of cholesterol and other lipids.
Killilea, DW, Firnkes, S, Yanjanin, N, Hastings, C, Ganio, G, Bush, AI, Walterfang, M, Hung, YH, Ory, DS, Porter, FD, Faux, NG, Volitakis, I   +11 more
core   +1 more source

A Multifunctional Ionograsper Enabling Ion‐Redistribution Proximity Sensing and Structural‐Reconfiguration‐Driven Bidirectional Actuation

Advanced Materials, EarlyView.
A solid‐state ionic actuator integrates sensing, actuation, and memory within one material. A brief UV pulse induces long‐lasting deformation via coupled network rearrangement, dehydration, and rehydration, while ionic redistribution enables self‐powered sensing, supporting multifunctional, energy‐efficient soft robotic functions without continuous ...
Yong Min Kim, Jin Han Kwon, Hyeon Woo Yang, Sungryong Kim, Gyeong Rok Lee, Hong Chul Moon   +5 more
wiley   +1 more source

Calcium Rescues Streptococcus pneumoniae D39 ΔmntE Manganese-Sensitive Growth Phenotype

Microorganisms
Calcium (Ca2+) functions as a universal signal messenger in eukaryotes but in bacteria, the physiological roles for Ca2+ are limited. Here, we examine the role of Ca2+ in Streptococcus pneumoniae during manganese (Mn2+) intoxication. S.
Reuben Opoku, Edgar Carrasco, Nicholas R. De Lay, Julia E. Martin   +3 more
doaj   +1 more source