Results 51 to 60 of about 9,360 (305)
Polar reactions of acyclic conjugated bisallenes
Beilstein Journal of Organic Chemistry, 2013 The chemical behaviour of various alkyl-substituted, acyclic conjugated bisallenes in reactions involving polar intermediates and/or transition states has been investigated on a broad scale for the first time.
Reiner Stamm, Henning Hopf
doaj +1 more source
Protein Metalation by Inorganic Anticancer Drugs
, 2020 Today, there is a growing awareness that proteins, beyond nucleic acids, represent primary druggable targets for anticancer metal‐based agents. Indeed, it has been unambiguously ascertained that the coordinative binding of metal‐based drugs to selected ...
Messori, Luigi +7 more
core +1 more source
Regioselective Syntheses and Functionalizations of Polycyclic Aromatic Hydrocarbons: Directed Metalation and C─H Activation [PDF]
, 2019 Polycyclic aromatic hydrocarbons (PAHs) are well-known as pollutants and carcinogenic compounds. Lately, considering their opto-electronic and photophysical properties, PAHs are being developed as materials to be used in electronics, non-linear optics ...
Kancherla, Sindhu
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines
Beilstein Journal of Organic Chemistry, 2017 Oxoisoaporphine alkaloids are conveniently prepared via direct ring metalation of alkoxy-substituted isoquinolines at C-1, followed by reaction with iodine.
Benedikt C. Melzer, Franz Bracher
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Carbonyl-to-nickel exchange on a lactam skeleton
Communications Chemistry, 2023 Molecular skeletal editing has a wide range of applications in late-stage derivatization, but metal–carbon exchange is underexplored due to the challenges in selectively cleaving highly inert chemical bonds and forming stable intermediates.
Huijuan Guo
doaj +1 more source
Interplay between Carbonic Anhydrases and Metallothioneins: Structural Control of Metalation
, 2020 Carbonic anhydrases (CAs) and metallothioneins (MTs) are both families of zinc metalloproteins central to life, however, they coordinate and interact with their Zn2+ ion cofactors in completely different ways.
Martin J. Stillman +3 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source