Results 31 to 40 of about 9,360 (305)
2-Diphenylphosphinomethyl-3-methylpyrazine
Molbank, 2021 The lateral metalation-electrophilic trapping reaction of alkyl-substituted pyrazines has always been challenging and poorly regioselective, with the corresponding derivatives often being isolated in moderate yield.
Tiziana Boccuzzi +6 more
doaj +1 more source
Chemical Activation of a Single Melamine Molecule via Isomerization Followed by Metalation with a Copper Atom. [PDF]
ACS NanoScanning probe methods have very successfully been used for inducing on-surface reactions and imaging with high resolution the reaction partners at the single-molecule level. However, the entire sequence of chemically activating an educt, identifying its
Rothe K +4 more
europepmc +2 more sources
Metalation: nature’s challenge in bioinorganic chemistry
, 2020 The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra mechanisms for tricky combinations ...
Glasfeld, Arthur, Robinson, Nigel J.
core +1 more source
Regiospecific Metalation of Oligobromobenzenes
, 2016 The metalation of selected oligobromobenzenes with lithium diisopropylamide (LDA) was investigated. 1,3-Dibromo-substituted benzenes were metalated without special precautions since the resultant 2,6-dibromophenyllithium intermediates are relatively ...
Sergiusz Luliński (2730013) +1 more
core +2 more sources
Bidentate Lewis Acids Derived from o‐Diethynylbenzene with Group 13 and 14 Functions
ChemistryOpen, 2021 Starting from 1,2‐diethynylbenzene, a series of bidentate Lewis acids was prepared by means of hydrometalations, in particular hydrosilylation, hydroboration, hydroalumination and terminal metalation based on group 13 and 14 elements.
Jens Rudlof +5 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2019 Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl∙LiCl at −40 °C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the ...
Benedikt C. Melzer +2 more
doaj +1 more source
Frontiers in Chemical BiologyOver the past 2 decades, solid evidence has emerged to suggest that the mode of action of certain classes of metal-based anti-cancer drugs (e.g., several ruthenium and gold compounds) is largely mediated by their interaction with cellular proteins rather
Antonello Merlino +2 more
doaj +1 more source
Nature Communications, 2021 The connection between metal binding to proteins and availabilities of different metals in cells has been unclear. Here, the authors report a metalation-calculator that takes into account competition between metals and their variable accessibility, and ...
Tessa R. Young +8 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2012 A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone ...
Raymond C. F. Jones +5 more
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Molecules, 2023 Gold compounds form a new class of promising anticancer agents with innovative modes of action. It is generally believed that anticancer gold compounds, at variance with clinically established platinum drugs, preferentially target proteins rather than ...
Andrea Geri, Lara Massai, Luigi Messori
doaj +1 more source