Results 81 to 90 of about 9,360 (305)

catena-Poly[silver(I)-μ-[1-(pyridin-2-ylmethyl-κN)-3-(3-sulfonatopropyl)imidazolin-2-ylidene]-κC2]

IUCrData, 2016
The title compound, [Ag(C12H14N3O3S)]n, was obtained by deprotonation and metalation of 1-(pyridin-2-ylmethyl)-3-(3-sulfopropyl)imidazolium, inner salt, using silver(I) oxide in methanol.
Barbara Rietzler, Gerhard Laus, Volker Kahlenberg, Herwig Schottenberger   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Structural and Mechanistic Insights into the Metalation of Fluoroarenes Mediated by a Superbasic Co(II) Bis(amide) Complex

CHIMIA
Over the past decades, s-block metal amides including LiTMP and TMPMgCl.LiCl (TMP = 2,2,6,6-tetramethylpiperidide) have found widespread applications in the deprotonative metalation of aromatic compounds.
Na Jin, Eva Hevia
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A short and efficient synthesis of valsartan via a Negishi reaction

Beilstein Journal of Organic Chemistry, 2010
An efficient synthesis of the angiotensin-II inhibitor valsartan (Diovan®) is presented. Directed ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis.
Samir Ghosh, A. Sanjeev Kumar, G. N. Mehta   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Bond Formation at C8 in the Nucleoside and Nucleotide Purine Scaffold: An Informative Selection

Molecules
This paper presents methods for the introduction and exchange of substituents in a nucleobase and its nucleosides and nucleotides with emphasis on the C8-position in the purine skeleton. The nucleobase is open for electrophilic and nucleophilic chemistry.
Kjell Undheim
doaj   +1 more source

Long-range Effect of Bromine in the Deprotonative Metalation of Aromatic Compounds

CHIMIA, 2016
Deprotonative metalation has been largely used to functionalize aromatic compounds. The efficiency of such reactions, as well as their regioselectivity, depends on the substituents connected to the rings.
Florence Mongin
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

N- versus S-Metalation of Nitridobis(3,4-toluenedithiolato)osmium(VI)

, 2016
N- versus S-Metalation of Nitridobis(3,4-toluenedithiolato)osmium ...
Joyce L. C. Chim (2963430), Wing-Tak Wong (1616416), Wa-Hung Leung (1753816)   +2 more
core   +1 more source