Results 31 to 40 of about 241,759 (268)

Size-dependent vitrification in metallic glasses

Nature Communications, 2023
Reducing the sample size can profoundly impact properties of bulk metallic glasses. Here, we systematically reduce the length scale of Au and Pt-based metallic glasses and study their vitrification behavior and atomic mobility.
Valerio Di Lisio, Isabella Gallino, Sascha Sebastian Riegler, Maximilian Frey, Nico Neuber, Golden Kumar, Jan Schroers, Ralf Busch, Daniele Cangialosi   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of composition and thermal history on deformation behavior and cluster connections in model bulk metallic glasses

Scientific Reports, 2022
The compositional dependence and influence of relaxation state on the deformation behavior of a Pt–Pd-based bulk metallic glasses model system was investigated, where platinum is systematically replaced by topologically equivalent palladium atoms.
Nico Neuber, Maryam Sadeghilaridjani, Nandita Ghodki, Oliver Gross, Bastian Adam, Lucas Ruschel, Maximilian Frey, Saideep Muskeri, Malte Blankenburg, Isabella Gallino, Ralf Busch, Sundeep Mukherjee   +11 more
doaj   +1 more source

Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery

Bioengineering, 2022
Though surgical techniques profoundly influence in vivo experiments, significant heterogeneity exists in current surgeries for inducing rat femoral bone defects. Such variations reduce the reproducibility and comparability of preclinical studies, and are
Yu Sun, Heike Helmholz, Regine Willumeit-Römer   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Fabrication of Textile Waste Fibers Aerogels with Excellent Oil/Organic Solvent Adsorption and Thermal Properties

Gels, 2022
In recent years, the treatment of textile waste has attracted more and more attention around the world. The reuse of textile waste can contribute to the reduction of carbon emissions and the sustainable development of the economy.
Chunlei Dong, Yangzhao Hu, Yuxuan Zhu, Jiale Wang, Xuerui Jia, Jianbing Chen, Jingliang Li   +6 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Effects of Surface Treatment Processes of SiC Ceramic on Interfacial Bonding Property of SiC-AFRP

Cailiao gongcheng, 2016
To improve the interfacial bonding properties of SiC-aramid fiber reinforced polymer matrix composites (SiC-AFRP), the influences of etching process of SiC ceramic, coupling treatment process, and the adhesives types on the interfacial peel strength of ...
WEI Ru-bin, LI Feng, LIANG Yong-fang, ZHAI Wen, ZHANG Wen-ting, CHEN Qing-xiang   +5 more
doaj   +1 more source

Multicolor Histochemical Staining for Identification of Mineralized and Non-Mineralized Musculoskeletal Tissue: Immunohistochemical and Radiological Validation in Decalcified Bone Samples

Bioengineering, 2022
Histochemical staining of paraffin-embedded decalcified bone samples is commonly used in preclinical research of musculoskeletal diseases, enabling the visualization of multiple tissue components by the application of chromogens.
Yu Sun, Heike Helmholz, Regine Willumeit-Römer   +2 more
doaj   +1 more source