Results 41 to 50 of about 1,142,756 (298)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effects of Surface Treatment Processes of SiC Ceramic on Interfacial Bonding Property of SiC-AFRP

Cailiao gongcheng, 2016
To improve the interfacial bonding properties of SiC-aramid fiber reinforced polymer matrix composites (SiC-AFRP), the influences of etching process of SiC ceramic, coupling treatment process, and the adhesives types on the interfacial peel strength of ...
WEI Ru-bin, LI Feng, LIANG Yong-fang, ZHAI Wen, ZHANG Wen-ting, CHEN Qing-xiang   +5 more
doaj   +1 more source

Fabrication of Textile Waste Fibers Aerogels with Excellent Oil/Organic Solvent Adsorption and Thermal Properties

Gels, 2022
In recent years, the treatment of textile waste has attracted more and more attention around the world. The reuse of textile waste can contribute to the reduction of carbon emissions and the sustainable development of the economy.
Chunlei Dong, Yangzhao Hu, Yuxuan Zhu, Jiale Wang, Xuerui Jia, Jianbing Chen, Jingliang Li   +6 more
doaj   +1 more source

Coexistence of Weak Localization and a Metallic Phase in Si/SiGe Quantum Wells

, 1999
Magnetoresistivity measurements on p-type Si/SiGe quantum wells reveal the coexistence of a metallic behavior and weak localization. Deep in the metallic regime, pronounced weak localization reduces the metallic behavior around zero magnetic field ...
A. R. Hamilton, A.M. Finkelstein, B. J. F. Lin, B. L. Altshuler, B. L. Altshuler, B. L. Altshuler, B. L. Altshuler, C. Castellani, C. J. Emeleus, D. Grützmacher, D. Popovic, D. Simonian, D. Simonian, D. Simonian, E. Abrahams, E. Ribeiro, G. Brunthaler, G. Dehlinger, H. Fukuyama, J. Lam, J. Yoon, K. Ensslin, K. M. Mertes, M. Ortuno, M. S. Burdis, M. Y. Simmons, P. A. Lee, P. Mohanty, P. Phillips, P. T. Coleridge, Q. Si, S. Chakravarty, S. Das Sarma, S. He, S. Hikami, S. J. Papadakis, S. J. Papadakis, S. V. Kravchenko, S. V. Kravchenko, S. V. Kravchenko, S. V. Kravchenko, S. V. Kravchenko, T. Hassenkam, T. Heinzel, T. Ihn, T. Okamoto, U. Gennser, V. Dobrosavljevic, V. M. Pudalov, V. M. Pudalov, V. M. Pudalov, V. Senz, V. Senz, X. G. Feng, Y. Hanein, Y. Hanein, Y. Hanein, Y. Hanein, Y. Ren   +58 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source