Results 51 to 60 of about 7,747 (222)

An electrophile-nucleophile interaction in metalloprotein structures. Prot Sci [PDF]

, 1997
A new attractive interaction in metalloprotein structures, between the thiolate anion of a metal-bound cysteine (acting as a nucleophile) and a carbonyl carbon of a peptide group (an electrophile), has been identified.
Pal, Debnath, Chakrabarti, Pinak, Pinak Chakrabarti, Debnath Pal   +3 more
core   +1 more source

Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV

Biomolecules
The ReAV enzyme from Rhizobium etli, a representative of Class 3 L-asparaginases, is sequentially and structurally different from other known L-asparaginases. This distinctiveness makes ReAV a candidate for novel antileukemic therapies.
Kinga Pokrywka, Marta Grzechowiak, Joanna Sliwiak, Paulina Worsztynowicz, Joanna I. Loch, Milosz Ruszkowski, Miroslaw Gilski, Mariusz Jaskolski   +7 more
doaj   +1 more source

Engineering Metalloprotein Functions in Designed and Native Scaffolds

, 2019
Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins makes metalloproteins able to accomplish key processes in biological systems, often very difficult to reproduce with inorganic coordination compounds under ...
Leone L., Zambrano G., Lombardi A., D'Alonzo D., Nastri F., Pavone V.   +5 more
core   +1 more source

Single-metalloprotein wet biotransistor

, 2005
Metalloproteins are redox molecules naturally shuttling electrons with high efficiency between molecular partners. As such, they are candidates of choice for bioelectronics.
SALERNO M., ALESSANDRINI, Andrea, Frabboni S, Facci P, Alessandrini A, FACCI P., FRABBONI, Stefano, Salerno M   +7 more
core   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

α-Lactalbumin: A calcium metalloprotein

, 1980
Metal analyses and the studies of the effects of EDTA on unfolding reactions have shown that α-lactalbumin is a calcium metalloprotein. The role of the calcium binding in its biological activity is considered.
桑島, 邦博, HIRAOKA, Yoshiki, MURAI, Norio, SEGAWA, Tatsuhisa, SUGAI, Shintaro, KUWAJIMA, Kunihiro   +5 more
core   +1 more source

Metal ion assisted folding and supramolecular organization of a de novo designed metalloprotein

, 2004
This paper describes the supramolecular organization of a novel de novo designed metalloprotein, which consists of two N-terminal terpyridine modified coiled-coil protein folding motif sequences held together by an iron(II) ion.
Schubert, U., Vandermeulen, G.W.M., Alexeev, A., Schubert, U. S., Klok, H., Schubert, D., Klok, Harm-Anton, Schubert, U.S., Andres, P., Tziatzios, C., Andres, P. R., Vandermeulen, G. W. M., Vandermeulen, G., Klok, H.-A., Klok, H.A., Andres, P.R.   +15 more
core   +1 more source

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

Journal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Macroscopic Convective Fluid Flows Arising From Binding of Ions and Small Molecules to Proteins

Small, EarlyView.
The interaction of ions or small molecules with proteins causes convective flows due to the displacement of water from the hydration shell. As shown, the replacement of the nickel ion removed from urease by EDTA pre‐treatment results in binding‐induced convective fluid flow.
Shanid Babu Shrestha, Jiaqi Song, Ali Heydari, Igor S. Aranson, Ayusman Sen   +4 more
wiley   +1 more source

Triggered infrared spectroscopy for investigating metalloprotein chemistry.

, 2010
Recent developments in infrared (IR) spectroscopic time resolution, sensitivity and sample manipulation make this technique a powerful addition to the suite of complementary approaches for the study of time-resolved chemistry at metal centres within ...
Kylie A. Vincent, Vincent, Kylie, Vincent, KA   +2 more
core   +1 more source