Results 41 to 50 of about 7,747 (222)
RPL6: A Key Molecule Regulating Zinc- and Magnesium-Bound Metalloproteins of Parkinson’s Disease
Frontiers in Neuroscience, 2021 Parkinson’s disease (PD) is a progressive neurodegenerative disease with no definite molecular markers for diagnosis. Metal exposure may alter cellular proteins that contribute to PD.
Athira Anirudhan +7 more
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Designed metalloprotein stabilizes a semiquinone radical [PDF]
, 2016 Enzymes use binding energy to stabilize their substrates in high-energy states that are otherwise inaccessible at ambient temperature. Here we show that a de novo designed Zn(II) metalloprotein stabilizes a chemically reactive organic radical that is ...
William F. DeGrado +9 more
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Computational Treatment of Metalloproteins [PDF]
The Journal of Physical Chemistry B, 2015 Metalloproteins present a considerable challenge for modeling, especially when the starting point is far from thermodynamic equilibrium. Examples include formidable problems such as metalloprotein folding and structure prediction upon metal addition, removal, or even just replacement; metalloenzyme design, where stabilization of a transition state of ...
Nechay, Michael R +2 more
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Machine learning differentiates enzymatic and non-enzymatic metals in proteins
Nature Communications, 2021 The authors generate the largest structural dataset of enzymatic and non-enzymatic metalloprotein sites to date. They use this dataset to train a decision-tree ensemble machine learning algorithm that allows them to distinguish between catalytic and non ...
Ryan Feehan +2 more
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Metalloproteins in the Biology of Heterocysts [PDF]
Life, 2019 Cyanobacteria are photoautotrophic microorganisms present in almost all ecologically niches on Earth. They exist as single-cell or filamentous forms and the latter often contain specialized cells for N2 fixation known as heterocysts. Heterocysts arise from photosynthetic active vegetative cells by multiple morphological and physiological rearrangements
Pernil, Rafael, Schleiff, Enrico
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Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients. [PDF]
PLoS ONE, 2015 Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the ...
Michael Syka +7 more
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, 2017 The metalloprotein-inspired Ru complex (3) was prepared via molecular convolution from linear amphiphilic polymer poly(N-isopropylacrylamide-co-N-vinylimidazole) (1) and ruthenium trichloride (2).
Ajay Gupta (841979) +3 more
core +1 more source
Decorin Is a Zn2+ Metalloprotein [PDF]
Journal of Biological Chemistry, 1999 Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang +4 more
openaire +2 more sources
Clustering as a Means To Control Nitrate Respiration Efficiency and Toxicity in
mBio, 2019 Respiration is a fundamental process that has to optimally respond to metabolic demand and environmental changes. We previously showed that nitrate respiration, crucial for gut colonization by enterobacteria, is controlled by polar clustering of the ...
Suzy Bulot +8 more
doaj +1 more source
Human CTR1 Through the Ages: Milestones and Emerging Roles in Disease and Therapy
BiomoleculesCopper transporter 1 (CTR1) is the primary high affinity importer for Cu(I) in eukaryotic cells. CTR1 plays an essential role in maintaining copper homeostasis which is crucial for diverse biological processes.
Shahaf Peleg +2 more
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