Results 21 to 30 of about 7,747 (222)

Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

Molecules, 2021
Globally, human exposure to environmental pollutants causes an estimated 9 million deaths per year and it could also be implicated in the etiology of diseases that do not appear to have a genetic origin.
Tristen G. Bridle, Premkumari Kumarathasan, Jürgen Gailer   +2 more
doaj   +1 more source

Conformational selection underlies recognition of a molybdoenzyme by its dedicated chaperone. [PDF]

PLoS ONE, 2012
Molecular recognition is central to all biological processes. Understanding the key role played by dedicated chaperones in metalloprotein folding and assembly requires the knowledge of their conformational ensembles.
Magali Lorenzi, Léa Sylvi, Guillaume Gerbaud, Elisabetta Mileo, Frédéric Halgand, Anne Walburger, Hervé Vezin, Valérie Belle, Bruno Guigliarelli, Axel Magalon   +9 more
doaj   +1 more source

Metalloprotein AlphaFold set with enzyme/non-enzyme labeled sites

, 2023
The AlphaFold set contains computationally generated structures for metalloproteins that were used to test MAHOMES II's enzyme/non-enzyme predictive performance (Feehan et al. 2023).
Feehan, Ryan
core   +2 more sources

Functional Expression and Characterization of a Panel of Cobalt and Iron-Dependent Nitrile Hydratases

Molecules, 2020
Nitrile hydratases (NHase) catalyze the hydration of nitriles to the corresponding amides. We report on the heterologous expression of various nitrile hydratases.
Birgit Grill, Maximilian Glänzer, Helmut Schwab, Kerstin Steiner, Daniel Pienaar, Dean Brady, Kai Donsbach, Margit Winkler   +7 more
doaj   +1 more source

Inter-Subunit Dynamics Controls Tunnel Formation During the Oxygenation Process in Hemocyanin Hexamers

Frontiers in Molecular Biosciences, 2021
Hemocyanin from horseshoe crab in its active form is a homo-hexameric protein. It exists in open and closed conformations when transitioning between deoxygenated and oxygenated states.
Khair Bux, Xiayu Shen, Muhammad Tariq, Junqi Yin, Syed Tarique Moin, Debsindhu Bhowmik, Shozeb Haider   +6 more
doaj   +1 more source

Frontiers in metalloprotein crystallography and cryogenic electron microscopy

, 2022
Metalloproteins comprise at least a third of all proteins that utilize redox properties of transition metals on their own or as parts of cofactors. The development of third generation storage ring sources and X-ray free-electron lasers with femtosecond ...
Gopalasingam, CC, Hasnain, SS
core   +1 more source

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography

eLife, 2022
Redox reactions are central to biochemistry and are both controlled by and induce protein structural changes. Here, we describe structural rearrangements and crosstalk within the Bacillus cereus ribonucleotide reductase R2b–NrdI complex, a di-metal ...
Juliane John, Oskar Aurelius, Vivek Srinivas, Patricia Saura, In-Sik Kim, Asmit Bhowmick, Philipp S Simon, Medhanjali Dasgupta, Cindy Pham, Sheraz Gul, Kyle D Sutherlin, Pierre Aller, Agata Butryn, Allen M Orville, Mun Hon Cheah, Shigeki Owada, Kensuke Tono, Franklin D Fuller, Alexander Batyuk, Aaron S Brewster, Nicholas K Sauter, Vittal K Yachandra, Junko Yano, Ville RI Kaila, Jan Kern, Hugo Lebrette, Martin Högbom   +26 more
doaj   +1 more source

NMR Studies of Metalloproteins [PDF]

, 2011
Metalloproteins represent a large share of the proteomes, with the intrinsic metal ions providing catalytic, regulatory, and structural roles critical to protein functions. Structural characterization of metalloproteins and identification of metal coordination features including numbers and types of ligands and metal-ligand geometry, and mapping the ...
Sun, H, Li, H
openaire   +4 more sources

Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

Frontiers in Cellular and Infection Microbiology, 2022
Transition metals are essential for metalloprotein function among all domains of life. Humans utilize nutritional immunity to limit bacterial infections, employing metalloproteins such as hemoglobin, transferrin, and lactoferrin across a variety of ...
Julie Lynn Stoudenmire, Ashley Nicole Greenawalt, Cynthia Nau Cornelissen   +2 more
doaj   +1 more source

How Theoretical Evaluations Can Generate Guidelines for Designing/Engineering Metalloproteins with Desired Metal Affinity and Selectivity

Molecules, 2022
Almost half of all known proteins contain metal co-factors. Crucial for the flawless performance of a metalloprotein is the selection with high fidelity of the cognate metal cation from the surrounding biological fluids.
Todor Dudev
doaj   +1 more source