Metalloprotein‐based MRI probes [PDF]
FEBS Letters, 2013 Metalloproteins have long been recognized as key determinants of endogenous contrast in magnetic resonance imaging (MRI) of biological subjects. More recently, both natural and engineered metalloproteins have been harnessed as biotechnological tools to probe gene expression, enzyme activity, and analyte concentrations by MRI.
Matsumoto, Yuri, Jasanoff, Alan Pradip
core +6 more sources
Bioinformatics of Metalloproteins and Metalloproteomes [PDF]
Molecules, 2020 Trace metals are inorganic elements that are required for all organisms in very low quantities. They serve as cofactors and activators of metalloproteins involved in a variety of key cellular processes.
Yan Zhang, Junge Zheng
doaj +3 more sources
Discovery and cryoEM structure of FPM13, a periplasmic metalloprotein unique to Francisella [PDF]
PLoS PathogensWe report the identification and cryoEM structure of the Francisella protein FTN_1118, a previously uncharacterized 13 kDa periplasmic protein unique to the Francisella genus.
Daniel L. Clemens +4 more
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Recent advances and future challenges in predictive modeling of metalloproteins by artificial intelligence [PDF]
Molecules and Cells: Metal coordination is essential for structural/catalytic functions of metalloproteins that mediate a wide range of biological processes in living organisms. Advances in bioinformatics have significantly enhanced our understanding of metal-binding sites
Soohyeong Kim +4 more
doaj +2 more sources
Improving Data Representation of Metalloproteins in the Protein Data Bank [PDF]
Structural DynamicsThe Protein Data Bank (PDB) was established in 1971 as the first open-access digital data resource in biology, initially comprising just seven X- ray crystal structures of proteins.
Alison Biester +6 more
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Methanogenesis marker 16 metalloprotein is the primary coenzyme M synthase in Methanosarcina acetivorans. [PDF]
PLoS Genetics2-mercaptoethanesulfonate (Coenzyme M, CoM) is an organic sulfur-containing cofactor used for hydrocarbon metabolism in archaea and bacteria. In archaea, CoM serves as an alkyl group carrier for enzymes belonging to the alkyl-CoM reductase family ...
Grayson L Chadwick +3 more
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Investigation of the Ferredoxin’s Influence on the Anaerobic and Aerobic, Enzymatic H2 Production
Frontiers in Bioengineering and Biotechnology, 2021 Ferredoxins are metalloproteins that deliver electrons to several redox partners, including [FeFe] hydrogenases that are potentially a component of biological H2 production technologies.
Jamin Koo, Yeeun Cha
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Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry
mBio, 2022 Copper (Cu) is an essential micronutrient for cells, but in excess it is cytotoxic. How Cu is cytotoxic is the subject of recent work by L. Zuily, N.
Charlotte I. Z. O’Hern +1 more
doaj +1 more source
Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli
Nature Communications, 2022 New cryo-EM structures of the formate hydrogenlyase complex from the model bacterium E. coli clarify how electrons and protons move through the complex and are combined to make H2 gas.
Ralf Steinhilper +3 more
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Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source