Results 81 to 90 of about 32,940 (209)

Role of laminin bioavailability in the astroglial permissivity for neuritic outgrowth

Anais da Academia Brasileira de Ciências, 2002
The mechanisms involved in the failure of an adult brain to regenerate post-lesion remain poorly understood. The reactive gliosis which occurs after an injury to the CNS and leads to the glial scar has been considered as one of the major impediments to ...
TARDY MARCIENNE
doaj  

Matrix metalloproteinase activation and TNF upregulation characterize the sclerotic phase of aortic valve disease

British Journal of Biomedical Science
IntroductionAortic valve sclerosis (AVSc) is an active pathological process driven by extracellular matrix remodeling, consistent with a potentially reversible early stage of aortic valve disease.MethodsIn this cross-sectional study of 168 participants ...
Elizabeth Chan-Delgado, Elizabeth Chan-Delgado, Elizabeth Chan-Delgado, Claudia Lerma, Juan C. Echeverría, Andrea Toledo, José M. Torres-Arellano, Oscar Infante, Rafael Bojalil, Jorge E. Cossío-Aranda, Nydia Ávila-Vanzzini, Nydia Ávila-Vanzzini, Luis M. Amezcua-Guerra, Luis M. Amezcua-Guerra, Luis M. Amezcua-Guerra, Rashidi Springall   +15 more
doaj   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Metalloproteinases in chronic and acute wounds: A systematic review and meta-analysis

, 2019
A systematic review and meta-analysis were undertaken in order to explore the influence of matrix metalloproteinases and their diagnostic methods in chronic and acute wounds. Searches were conducted in the PubMed (Medline) and Embase (Elsevier) databases
Tardaguila García, Aroa, García Alamino, Josep María, García Morales, Esther Alicia, Álvaro Afonso, Francisco Javier, Molines Barroso, Raúl Juan, Lázaro Martínez, José Luis   +5 more
core   +1 more source

Metalloproteinases: a Functional Pathway for Myeloid Cells [PDF]

, 2016
Myeloid cells have diverse roles in regulating immunity, inflammation, and extracellular matrix turnover. To accomplish these tasks, myeloid cells carry an arsenal of metalloproteinases, which include the matrix metalloproteinases and the adamalysins ...
Werb, Zena, Jonathan Chou, Matilda F. Chan, Zena Werb, Chou, Jonathan, Chan, Matilda F   +5 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Matrix metalloproteinases in exercise and obesity [PDF]

, 2016
Jonathan Jaoude,1 Yunsuk Koh2 1Department of Biology, 2Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA Abstract: Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent endoproteinases that have the ...
Jaoude J, Koh Y
core  

Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma [PDF]

, 2017
Extracellular matrix metalloproteinases - MMPs, also referred to as matrixines, provide a group of proteolytic enzymes. They belong to the family of endopeptidases that break down elements of extracellular matrix, resulting in its continuous remodelling.
Młynarczyk, G., Romanowicz, L., L. Romanowicz, G. Młynarczyk, Kudelski, J., Z. Galewska, Darewicz, B., J. Kudelski, B. Darewicz, Galewska, Z.   +9 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source