Results 141 to 150 of about 27,575 (332)
High-resolution electrochemical STM of redox metalloproteins [PDF]
, 2017 Electrochemical studies of redox active metalloproteins have become an increasingly fruitful area of study in recent years, particularly with the single-molecule resolution capability of electrochemical scanning tunnelling microscopy (EC-STM) which ...
Elliott, Martin
core +2 more sources
Experimental Physiology, EarlyView.Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto +10 more
wiley +1 more source
Magnetic Relaxometry of Methemoglobin by Widefield Nitrogen-Vacancy Microscopy [PDF]
Appl. Phys. Lett. 125, 114002 (2024)Hemoglobin (Hb) is a multifaceted protein, classified as a metalloprotein, chromoprotein, and globulin. It incorporates iron, which plays a crucial role in transporting oxygen within red blood cells. Hb functions by carrying oxygen from the respiratory organs to diverse tissues in the body, where it releases oxygen to fuel aerobic respiration, thus ...
arxiv +1 more source
Metallochaperones regulate intracellular copper levels. [PDF]
, 2013 Copper (Cu) is an important enzyme co-factor that is also extremely toxic at high intracellular concentrations, making active efflux mechanisms essential for preventing Cu accumulation. Here, we have investigated the mechanistic role of metallochaperones
Adams, Michael +9 more
core +1 more source
Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley +1 more source
AutoDock4Zn: An Improved AutoDock Force Field for Small-Molecule Docking to Zinc Metalloproteins
Journal of Chemical Information and Modeling, 2014 Zinc is present in a wide variety of proteins and is important in the metabolism of most organisms. Zinc metalloenzymes are therapeutically relevant targets in diseases such as cancer, heart disease, bacterial infection, and Alzheimer’s disease.
Diogo Santos-Martins +3 more
semanticscholar +1 more source
Stick number of non-paneled knotless spatial graphs [PDF]
New York J. Math. 26 (2020), 836-852
http://nyjm.albany.edu/j/2020/26-38.html, 2019 We show that the minimum number of sticks required to construct a non-paneled knotless embedding of $K_4$ is 9 and of $K_5$ is 12 or 13. We use our results about $K_4$ to show that the probability that a random linear embedding of $K_{3,3}$ in a cube is in the form of a M\"{o}bius ladder is $0.97380\pm 0.00003$, and offer this as a possible explanation
arxiv
Journal of Computational Chemistry, Volume 46, Issue 16, June 15, 2025.In the context of the AMBER parameterization, a new force field is developed and validated for the simulation of cadmium(II)‐binding proteins. The proposed force field takes into account the polarization effect produced by the central ion on its surroundings.
Matteo Orlandi +5 more
wiley +1 more source
Bioavailability of Metal Ions and Evolutionary Adaptation
Life, 2012 The evolution of life on earth has been a long process that began nearly 3,5 x 109 years ago. In their initial moments, evolution was mainly influenced by anaerobic environments; with the rise of O2 and the corresponding change in bioavailability of ...
Rolando P. Hong Enriquez, Trang N. Do
doaj +1 more source
The Energetics of Electron Transfer in Redox‐DNA Layers Mimics That of Redox Proteins
Chemistry – A European Journal, Volume 31, Issue 33, June 12, 2025.The electron transfer in ferrocene‐labeled DNA (Fc‐DNA) layers mimics that of redox proteins, featuring a low reorganization energy (λ). The origin of the low λ in Fc‐DNA was unveiled by high‐scan‐rate cyclic voltammetry and molecular dynamics simulations, implying Fc‐DNA as a versatile tool to open new avenues in understanding the ET in biological ...
Zhiyong Zheng +5 more
wiley +1 more source