Results 81 to 90 of about 20,977 (223)
mBio, 2017 Copper (Cu) ions serve as catalytic cofactors to drive key biochemical processes, and yet Cu levels that exceed cellular homeostatic control capacity are toxic. The underlying mechanisms for Cu toxicity are poorly understood.
Sarela Garcia-Santamarina +4 more
doaj +1 more source
The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition
New Phytologist, Volume 250, Issue 3, Page 1619-1633, May 2026.Summary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Shunsuke Watanabe +7 more
wiley +1 more source
Computational Treatment of Metalloproteins [PDF]
The Journal of Physical Chemistry B, 2015 Metalloproteins present a considerable challenge for modeling, especially when the starting point is far from thermodynamic equilibrium. Examples include formidable problems such as metalloprotein folding and structure prediction upon metal addition, removal, or even just replacement; metalloenzyme design, where stabilization of a transition state of ...
Nechay, Michael R +2 more
openaire +4 more sources
Isolated Heme A Synthase from
mBio, 2020 The integral membrane protein heme A synthase (HAS) catalyzes the biosynthesis of heme A, which is a prerequisite for cellular respiration in a wide range of aerobic organisms.
Hui Zeng +9 more
doaj +1 more source
Insights from 125Te and 57Fe nuclear resonance vibrational spectroscopy: a [4Fe-4Te] cluster from two points of view. [PDF]
, 2019 Iron-sulfur clusters are common building blocks for electron transport and active sites of metalloproteins. Their comprehensive investigation is crucial for understanding these enzymes, which play important roles in modern biomimetic catalysis and ...
Apfel, Ulf-Peter +8 more
core +2 more sources
Novel roles of sulfur metabolism in stress‐controlled stomata aperture regulation
New Phytologist, Volume 250, Issue 3, Page 1460-1467, May 2026.Summary Stomatal closure allows plants to conserve water by reducing transpiration during drought. Surprisingly, the assimilation of the macronutrient sulfur is intimately connected to the drought stress response. This Tansley insight will only briefly touch on the general impact of sulfate assimilation on the production of drought‐response metabolites.
Sheng‐Kai Sun +2 more
wiley +1 more source
Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. [PDF]
, 2014 Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further
Diaz-Ochoa, Vladimir E +3 more
core +2 more sources
ChemMedChem, Volume 21, Issue 8, 28 April 2026.Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti +9 more
wiley +1 more source
eLife, 2016 The metallocofactor involved in fixing nitrogen is not a rigid scaffold, as was previously thought.
Percival Yang-Ting Chen +2 more
doaj +1 more source