Results 81 to 90 of about 14,121 (262)
Unlocking Precision Docking for Metalloproteins
Metalloproteins play a fundamental role in molecular biology, contributing to various biological processes. However, the discovery of high-affinity ligands targeting metalloproteins has been delayed due, in part, to a lack of suitable tools and data ...
Camila M. Clemente (17988815) +2 more
core +1 more source
XAFS Debye-Waller factors for Zn metalloproteins
, 2004 An accurate and practical method for the calculation and use of thermal x-ray absorption fine structure (XAFS) Debye-Waller factors (DWFs) in active sites of metalloproteins is presented.
Dimakis, Nicholas, Bunker, Grant
core +1 more source
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
Testing the limits: serial crystallography using unpatterned fixed targets
IUCrJSheet-on-sheet (SOS) fixed-target chips are arguably the most versatile, cheapest and simplest sample-delivery method for ambient-temperature data acquisition using serial crystallography approaches at synchrotrons and X-ray free-electron lasers (XFELs).
Alexander Gorel +12 more
doaj +1 more source
eLife, 2016 The metallocofactor involved in fixing nitrogen is not a rigid scaffold, as was previously thought.
Percival Yang-Ting Chen +2 more
doaj +1 more source
Magnetic Resonance in Chemistry, Volume 64, Issue 6, Page 584-593, June 2026.Real‐time in‐cell 19F NMR spectroscopy in a flow NMR bioreactor was used to monitor the binding of fluorinated compounds to three cytosolic carbonic anhydrase isoforms in living human cells. The simultaneous observation of the two ligands allowed for the quantitative ranking of their intracellular affinities by competition binding. This approach allows
Azzurra Costantino +5 more
wiley +1 more source
Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.Protein sequence surveys show that nickel‐ and molybdenum/copper‐containing carbon monoxide dehydrogenases (CODHs) are widespread in the ocean. Phylogenetic and genome context analyses reveal that marine CODHs are highly diverse in both evolutionary history and functional organisation.
Nipa Chongdar +2 more
wiley +1 more source
Bioavailability of Metal Ions and Evolutionary Adaptation
Life, 2012 The evolution of life on earth has been a long process that began nearly 3,5 x 109 years ago. In their initial moments, evolution was mainly influenced by anaerobic environments; with the rise of O2 and the corresponding change in bioavailability of ...
Rolando P. Hong Enriquez, Trang N. Do
doaj +1 more source
Fluorescent probes for zinc metalloproteins to study cellular zinc homeostasis
, 2022 Zinc and other metals in cells exist in two main forms: the labile or ‘free’ metal ion pool, and as metalloproteins where the metal ion is ‘tightly bound’ to the protein and necessary for structural, catalytic and regulatory functions in cells. Moreover,
Mehta, Radhika
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 6, Page 3754-3776, June 2026.ABSTRACT Iron (Fe) is an essential micronutrient for plant growth and development. The maintenance of Fe homeostasis relies on sophisticated regulatory networks where bHLH transcription factors play a key role. However, how these factors coordinate to regulate this vital process is not fully understood.
Fei Gao +13 more
wiley +1 more source