Results 61 to 70 of about 9,173 (177)
A Tale of Two Mechanisms: The p53 Modulator COTI‐2 Is a Zn Metallochaperone
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. Tp53 mutations often induce conformational changes that inhibit activity; however, small‐molecule chaperones could theoretically restore conformation and activity. COTI‐2,
İrem Şimşek +16 more
wiley +1 more source
Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review
eFood, Volume 7, Issue 4, August 2026.Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu +11 more
wiley +1 more source
Bioavailability of Metal Ions and Evolutionary Adaptation
Life, 2012 The evolution of life on earth has been a long process that began nearly 3,5 x 109 years ago. In their initial moments, evolution was mainly influenced by anaerobic environments; with the rise of O2 and the corresponding change in bioavailability of ...
Rolando P. Hong Enriquez, Trang N. Do
doaj +1 more source
Acta Crystallographica Section D, Volume 82, Issue 8, Page 886-899, August 2026.Small but measurable changes in the coordination geometry of a lytic polysaccharide monooxygenase copper active site are revealed by X‐ray crystallography, providing structural insight into their catalytic flexibility.Lytic polysaccharide monooxygenases (LPMOs) are copper‐dependent enzymes classified into the auxiliary activity (AA) families of the ...
Zhiyu Huang +7 more
wiley +1 more source
Acta Crystallographica Section D, Volume 82, Issue 8, Page 900-914, August 2026.A series of 36 structures of the Neurospora crassa LPMO NcAA9D were refined against X‐ray crystal datasets collected with increasing dose from a single crystal to provide insights into dose‐dependent structural changes at the active site of the enzyme.
Samuel A. Miller +2 more
wiley +1 more source
Clinical efficacy of reamberine in therapy for influenza
Терапевтический архив, 2010 Aim. To evaluate the tolerance and therapeutic effectiveness of 1.5% reamberine (RB) solution infusions in complex therapy for pneumonia-complicated pneumonia and acute respiratory diseases (ARD). Subjects and methods.
Valeriy Aleksandrovich Isakov +7 more
doaj
Point mutation in zinc sensor causes a threefold zinc level increase in Sorghum bicolor
New Phytologist, Volume 251, Issue 4, Page 1617-1624, August 2026.Point mutation in sensor triples zinc levels in Sorghum bicolor.
Feixue Liao +4 more
wiley +1 more source
The essential nutrient elements in photosynthesis
Frontiers in PhotobiologyEssential plant nutrient elements are “eaten” along with light in the process of photosynthesis, primarily in the leaves. Two pigment-protein systems embedded in the thylakoid membrane, Photosystem I and Photosystem II, mediate light absorption ...
Dmitry Shevela, Arthur Nonomura
doaj +1 more source
eLife, 2015 Dinitrogen reduction in the biological nitrogen cycle is catalyzed by nitrogenase, a two-component metalloenzyme. Understanding of the transformation of the inert resting state of the active site FeMo-cofactor into an activated state capable of reducing ...
Thomas Spatzal +3 more
doaj +1 more source
Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response
mBio, 2019 The cell wall is a strong, yet flexible, meshwork of peptidoglycan (PG) that gives a bacterium structural integrity. To accommodate a growing cell, the wall is remodeled by both PG synthesis and degradation.
Shannon G. Murphy +6 more
doaj +1 more source