Results 51 to 60 of about 20,977 (223)

Uranyl Binding to Proteins and Structural-Functional Impacts

Biomolecules, 2020
The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO22+).
Ying-Wu Lin
doaj   +1 more source

Mass spectrometry of B. subtilis CopZ: Cu(I)-binding and interactions with bacillithiol [PDF]

, 2016
CopZ from Bacillus subtilis is a well-studied member of the highly conserved family of Atx1-like copper chaperones. It was previously shown via solution and crystallographic studies to undergo Cu(I)-mediated dimerisation, where the CopZ dimer can bind ...
Andreini, Antelmann, Arguello, Banci, Banci, Banerjee, Barry, Blindauer, Chi, Chris J. Hamilton, Dalle-Donne, Dobo, Felitsyn, Gaballa, Hasler, Hearnshaw, Hopper, Housden, Hussain, Kaim, Kihlken, Kim, Kondrat, Kristine L. Kay, Lee, Luczkowski, Ma, Ma, Morin, Newton, Nick E. Le Brun, O'Halloran, Palumaa, Pountney, Prudent, Radford, Sharma, Sharma, Singleton, Singleton, Singleton, Sutherland, Urvoas, Wimmer, Xiao, Xiao, Zhou   +46 more
core   +1 more source

In silico Study of Iron, Zinc and Copper Binding Proteins of Pseudomonas syringae pv. lapsa: Emphasis on Secreted Metalloproteins

Frontiers in Microbiology, 2018
The phytopathogenic bacteria, Pseudomonas syringae pv. lapsa (P. syringae pv. lapsa) infects the staple food crop wheat. Metalloproteins play important roles in plant-pathogen interactions. Hence, the present work is aimed to predict and analyze the iron
Ankita Sharma, Dixit Sharma, Shailender K. Verma   +2 more
doaj   +1 more source

Engineering tyrosine-based electron flow pathways in proteins: The case of aplysia myoglobin [PDF]

, 2012
Tyrosine residues can act as redox cofactors that provide an electron transfer ("hole-hopping") route that enhances the rate of ferryl heme iron reduction by externally added reductants, for example, ascorbate.
Alayash A. I., Alayash A. I., Aubert C., Bolognesi M., Brandon J. Reeder, Chris E. Cooper, Dimitri A. Svistunenko, Egmond M. R., Ekberg M., Ekberg M., Gray H. B., Holt S., Lardinois O. M., McLeod L. L., Michael T. Wilson, Moore K. P., Natanson C., Nilges M. J., Peisach J., Reece S. Y., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Rogers M. S., Rova U., Rova U., Seyedsayamdost M. R., Shih C., Silaghi-Dumitrescu R., Stubbe J., Svistunenko D. A., Svistunenko D. A., Svistunenko D. A., Thompson M. K., Wilbur D. J., Yee C. S.   +39 more
core   +1 more source

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

Journal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Probing Metal Ion Discrimination in a Protein Designed to Bind Uranyl Cation With Femtomolar Affinity

Frontiers in Molecular Biosciences, 2019
The design of metal-binding sites in proteins that combine high affinity with high selectivity for the desired metal ion remains a challenging goal.
Marie Hoarau, Karl J. Koebke, Zhan Chen, E. Neil G. Marsh, E. Neil G. Marsh   +4 more
doaj   +1 more source

Organic and Inorganic Pollutants, Oxidative Stress Biomarkers, and Electrophoretic Protein Profiles in an Endangered Thresher Shark (Alopias vulpinus) From Southeastern Brazil: A Case Study

Environmental Toxicology, EarlyView.
ABSTRACT A comprehensive screening of different environmental contaminants (total metals, thermostable metal fractions associated with detoxification, and persistent organic pollutants) was conducted in an endangered common thresher shark (Alopias vulpinus ) individual incidentally captured in southeastern Brazil.
Sidney Fernandes Sales Junior, Amanda Pontes Lopes, Heloíse Martins de Souza, Regina Fonseca, Enrico Mendes Saggioro, Francielli Monteiro Casanova, Kamila Cezar Gramlich, Tatiana Dillenburg Saint'Pierre, Carlos German Massone, Renato Carreira, Rachel Ann Hauser‐Davis   +10 more
wiley   +1 more source

Reflections on the Origin of Coded Protein Biosynthesis

Biomolecules
The principle of continuity posits that some central features of primordial biocatalytic mechanisms should still be present in the genetically dependent pathway of protein synthesis, a crucial step in the emergence of life.
Juan Carlos Fontecilla-Camps
doaj   +1 more source

Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes

IUCrJ, 2016
Lytic polysaccharide monooxygenases (LPMOs) are a new class of microbial copper enzymes involved in the degradation of recalcitrant polysaccharides.
Kristian E. H. Frandsen, Leila Lo Leggio
doaj   +1 more source

Electron Transfer in Proteins [PDF]

, 1996
Electron-transfer (ET) reactions are key steps in a diverse array of biological transformations ranging from photosynthesis to aerobic respiration. A powerful theoretical formalism has been developed that describes ET rates in terms of two parameters ...
Gray, Harry B., Winkler, Jay R.
core   +1 more source