Results 31 to 40 of about 9,173 (177)
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi +1 more
wiley +1 more source
Computational Treatment of Metalloproteins [PDF]
The Journal of Physical Chemistry B, 2015 Metalloproteins present a considerable challenge for modeling, especially when the starting point is far from thermodynamic equilibrium. Examples include formidable problems such as metalloprotein folding and structure prediction upon metal addition, removal, or even just replacement; metalloenzyme design, where stabilization of a transition state of ...
Nechay, Michael R +2 more
openaire +4 more sources
Frontiers in Microbiology, 2018 The phytopathogenic bacteria, Pseudomonas syringae pv. lapsa (P. syringae pv. lapsa) infects the staple food crop wheat. Metalloproteins play important roles in plant-pathogen interactions. Hence, the present work is aimed to predict and analyze the iron
Ankita Sharma +2 more
doaj +1 more source
Uranyl Binding to Proteins and Structural-Functional Impacts
Biomolecules, 2020 The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO22+).
Ying-Wu Lin
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Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1
Chemistry – A European Journal, EarlyView.The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang +5 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2019 The design of metal-binding sites in proteins that combine high affinity with high selectivity for the desired metal ion remains a challenging goal.
Marie Hoarau +4 more
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Chemistry – A European Journal, EarlyView.Manganese oxides (MnOX) of different structures and with different Mn oxidation states exhibit significant variation in their reactivity toward the oxidation of allylic alcohols. Using two allylic alcohol model substrates, we demonstrate the relationship between activity and MnOX structure, Mn4+ content and incorporated secondary cations.
Erdogan Kasisari +6 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 33, 10 August 2026.Oxygen‐tolerant photo‐induced miniaturized accelerated atom transfer radical polymerization (OPTIMA‐ATRP) in water was developed for the polymerization of hydrophilic (meth)acrylate monomers under ambient or sub‐ambient (4°C) temperature and atmospheric conditions, without prior degassing, in less than 10 min, at an ultra‐small scale (< 50 µL) in ...
Arman Moini Jazani +5 more
wiley +2 more sources
Reflections on the Origin of Coded Protein Biosynthesis
BiomoleculesThe principle of continuity posits that some central features of primordial biocatalytic mechanisms should still be present in the genetically dependent pathway of protein synthesis, a crucial step in the emergence of life.
Juan Carlos Fontecilla-Camps
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IUCrJ, 2016 Lytic polysaccharide monooxygenases (LPMOs) are a new class of microbial copper enzymes involved in the degradation of recalcitrant polysaccharides.
Kristian E. H. Frandsen, Leila Lo Leggio
doaj +1 more source