Results 11 to 20 of about 9,549 (181)
Metalloproteins in the Biology of Heterocysts [PDF]
Life, 2019 Cyanobacteria are photoautotrophic microorganisms present in almost all ecologically niches on Earth. They exist as single-cell or filamentous forms and the latter often contain specialized cells for N2 fixation known as heterocysts.
Enrico Schleiff, Rafael Pernil
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Effects of Ionic Liquids on Metalloproteins
Molecules, 2021 In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline.
Chun Wu +2 more
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MBind: A Web-Based Platform for Metalloprotein and Nonmetalloprotein Docking with Optional ML Docking Integration [PDF]
MoleculesMetalloprotein docking is difficult because it requires precise preparation of the grid box, charge assignment, and metal coordination geometry. Many current graphical user interfaces (GUIs) do not support these steps well.
Harrish Ganesh +6 more
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Recent advances and future challenges in predictive modeling of metalloproteins by artificial intelligence [PDF]
Molecules and Cells: Metal coordination is essential for structural/catalytic functions of metalloproteins that mediate a wide range of biological processes in living organisms. Advances in bioinformatics have significantly enhanced our understanding of metal-binding sites
Soohyeong Kim +4 more
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Bioinformatics of Metalloproteins and Metalloproteomes [PDF]
Molecules, 2020 Trace metals are inorganic elements that are required for all organisms in very low quantities. They serve as cofactors and activators of metalloproteins involved in a variety of key cellular processes.
Yan Zhang, Junge Zheng
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Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state [PDF]
Quantitative Plant BiologyThe micronutrient zinc (Zn) is often poorly available but toxic when present in excess, so a tightly controlled Zn homoeostasis network operates in all organisms. This review summarizes our present understanding of plant Zn homoeostasis.
Ute Krämer
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Rational Design of Artificial Metalloproteins and Metalloenzymes with Metal Clusters
Molecules, 2019 Metalloproteins and metalloenzymes play important roles in biological systems by using the limited metal ions, complexes, and clusters that are associated with the protein matrix.
Ying-Wu Lin
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Structure and Catalytic Mechanism of Radical SAM Methylases
Life, 2022 Methyl transfer is essential in myriad biological pathways found across all domains of life. Unlike conventional methyltransferases that catalyze this reaction through nucleophilic substitution, many members of the radical S-adenosyl-L-methionine (SAM ...
Tu-Quynh Nguyen, Yvain Nicolet
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Nature Communications, 2022 ThiH is a radical SAM L-tyrosine lyase involved in the biosynthesis of the thiazole ring of vitamin B1. Here, the authors report the crystal structure of ThiH in complex with its L-tyrosine substrate, revealing an unexpected protonation state and ...
Patricia Amara +4 more
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Oxygen-Sensitive Metalloprotein Structure Determination by Cryo-Electron Microscopy
Biomolecules, 2022 Metalloproteins are involved in key cell processes such as photosynthesis, respiration, and oxygen transport. However, the presence of transition metals (notably iron as a component of [Fe-S] clusters) often makes these proteins sensitive to oxygen ...
Mickaël V. Cherrier +8 more
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