Results 21 to 30 of about 14,121 (262)
Structure and Catalytic Mechanism of Radical SAM Methylases
Life, 2022 Methyl transfer is essential in myriad biological pathways found across all domains of life. Unlike conventional methyltransferases that catalyze this reaction through nucleophilic substitution, many members of the radical S-adenosyl-L-methionine (SAM ...
Tu-Quynh Nguyen, Yvain Nicolet
doaj +1 more source
Oxygen-Sensitive Metalloprotein Structure Determination by Cryo-Electron Microscopy
Biomolecules, 2022 Metalloproteins are involved in key cell processes such as photosynthesis, respiration, and oxygen transport. However, the presence of transition metals (notably iron as a component of [Fe-S] clusters) often makes these proteins sensitive to oxygen ...
Mickaël V. Cherrier +8 more
doaj +1 more source
Nature Communications, 2022 ThiH is a radical SAM L-tyrosine lyase involved in the biosynthesis of the thiazole ring of vitamin B1. Here, the authors report the crystal structure of ThiH in complex with its L-tyrosine substrate, revealing an unexpected protonation state and ...
Patricia Amara +4 more
doaj +1 more source
Inorganics, 2023 The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic respiration, controlling the expression of >300 genes in response to O2 availability.
Jason C. Crack +8 more
doaj +1 more source
Communications Biology, 2022 The crystal structure of the iron-sulfur protein NsrR from Streptomyces coelicolor bound to a gene operator fragment is reported and compared with other structures, giving insight into the structural determinants of DNA recognition by the NO sensor.
Roman Rohac +6 more
doaj +1 more source
De Novo Engineering of Solid-State Metalloproteins Using Recombinant Coiled-Coil Silk
, 2015 To achieve the sophisticated chemistry required for life, nature uses metal containing proteins (metalloproteins). However, despite intensive research efforts, very few of these metalloproteins have been exploited for biotechnological applications.
Trevor D. Rapson +5 more
core +3 more sources
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Effects of Ionic Liquids on Metalloproteins
Molecules, 2021 In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline.
Aashka Y. Patel +5 more
doaj +1 more source
Molecules, 2021 Vibrational spectroscopy and in particular, resonance Raman (RR) spectroscopy, can provide molecular details on metalloproteins containing multiple cofactors, which are often challenging for other spectroscopies.
Célia M. Silveira +6 more
doaj +1 more source
Geobacter sulfurreducens’ Unique Metabolism Results in Cells with a High Iron and Lipid Content
Microbiology Spectrum, 2022 Geobacter sulfurreducens is a ubiquitous iron-reducing bacterium in soils, and in engineered systems, it can respire an electrode to produce measurable electric current.
Ethan Howley +3 more
doaj +1 more source