Results 21 to 30 of about 9,549 (181)

Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors

Communications Biology, 2022
The crystal structure of the iron-sulfur protein NsrR from Streptomyces coelicolor bound to a gene operator fragment is reported and compared with other structures, giving insight into the structural determinants of DNA recognition by the NO sensor.
Roman Rohac, Jason C. Crack, Eve de Rosny, Océane Gigarel, Nick E. Le Brun, Juan C. Fontecilla-Camps, Anne Volbeda   +6 more
doaj   +1 more source

Probing the Reactivity of [4Fe-4S] Fumarate and Nitrate Reduction (FNR) Regulator with O₂ and NO: Increased O₂ Resistance and Relative Specificity for NO of the [4Fe-4S] L28H FNR Cluster

Inorganics, 2023
The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic respiration, controlling the expression of >300 genes in response to O2 availability.
Jason C. Crack, Patricia Amara, Eve de Rosny, Claudine Darnault, Melanie R. Stapleton, Jeffrey Green, Anne Volbeda, Juan C. Fontecilla-Camps, Nick E. Le Brun   +8 more
doaj   +1 more source

Machine Learning Approaches for Metalloproteins

Molecules, 2022
Metalloproteins are a family of proteins characterized by metal ion binding, whereby the presence of these ions confers key catalytic and ligand-binding properties.
Yue Yu, Ruobing Wang, Ruijie D. Teo
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Molecular Details on Multiple Cofactor Containing Redox Metalloproteins Revealed by Infrared and Resonance Raman Spectroscopies

Molecules, 2021
Vibrational spectroscopy and in particular, resonance Raman (RR) spectroscopy, can provide molecular details on metalloproteins containing multiple cofactors, which are often challenging for other spectroscopies.
Célia M. Silveira, Lidia Zuccarello, Catarina Barbosa, Giorgio Caserta, Ingo Zebger, Peter Hildebrandt, Smilja Todorovic   +6 more
doaj   +1 more source

Geobacter sulfurreducens’ Unique Metabolism Results in Cells with a High Iron and Lipid Content

Microbiology Spectrum, 2022
Geobacter sulfurreducens is a ubiquitous iron-reducing bacterium in soils, and in engineered systems, it can respire an electrode to produce measurable electric current.
Ethan Howley, Dongwon Ki, Rosa Krajmalnik-Brown, César I. Torres   +3 more
doaj   +1 more source

Predicting copper-, iron- and zinc-binding proteins in pathogenic species of the Paracoccidioides genus

Frontiers in Microbiology, 2015
Approximately one-third of all proteins have been estimated to contain at least one metal cofactor, and these proteins are referred to as metalloproteins.
Gabriel B Tristao, Leandro Prado Assunção, Luiz Paulo Araujo Santos, CLAYTON LUIZ BORGES, Mirelle Garcia Silva-Bailao, Célia Maria de Almeida Soares, Gabriele eCavallaro, Alexandre Melo BAILAO   +7 more
doaj   +1 more source

In Silico Simulations Reveal Molecular Mechanism of Uranyl Ion Toxicity towards DNA-Binding Domain of PARP-1 Protein

Biomolecules, 2023
The molecular toxicity of the uranyl ion (UO22+) in living cells is primarily determined by its high affinity to both native and potential metal-binding sites that commonly occur in the structure of biomolecules.
Egor S. Bulavko, Marina A. Pak, Dmitry N. Ivankov   +2 more
doaj   +1 more source

Assessing the prospect of XAFS experiments of metalloproteins under in vivo conditions at Indus-2 synchrotron facility, India

Journal of Synchrotron Radiation, 2023
The feasibility of X-ray absorption fine-structure (XAFS) experiments of ultra-dilute metalloproteins under in vivo conditions (T = 300 K, pH = 7) at the BL-9 bending-magnet beamline (Indus-2) is reported, using as an example analogous synthetic Zn (0.1 ...
Debdutta Lahiri, Richa Agrawal, Khileshwari Chandravanshi, Parasmani Rajput, Ankur Agrawal, Ashutosh Dwivedi, Ravindra D. Makde, S. N. Jha, Nandini Garg   +8 more
doaj   +1 more source

How Theoretical Evaluations Can Generate Guidelines for Designing/Engineering Metalloproteins with Desired Metal Affinity and Selectivity

Molecules, 2022
Almost half of all known proteins contain metal co-factors. Crucial for the flawless performance of a metalloprotein is the selection with high fidelity of the cognate metal cation from the surrounding biological fluids.
Todor Dudev
doaj   +1 more source