Results 21 to 30 of about 9,173 (177)
Bioinformatic Mapping of Opine-Like Zincophore Biosynthesis in Bacteria
mSystems, 2020 Zinc is an essential nutrient in biological systems due to its structural or catalytic requirement in proteins involved in diverse cellular processes. To meet this cellular demand, microbes must acquire sufficient zinc from their environment.
Jacqueline R. Morey, Thomas E. Kehl-Fie
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NMR Studies of Metalloproteins [PDF]
, 2011 Metalloproteins represent a large share of the proteomes, with the intrinsic metal ions providing catalytic, regulatory, and structural roles critical to protein functions. Structural characterization of metalloproteins and identification of metal coordination features including numbers and types of ligands and metal-ligand geometry, and mapping the ...
Sun, H, Li, H
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The Stereochemical Basis of the Genetic Code and the (Mostly) Autotrophic Origin of Life
Life, 2014 Spark-tube experiments and analysis of meteorite contents have led to the widespread notion that abiotic organic molecules were the first life components.
Juan C. Fontecilla-Camps
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Zinc: Multidimensional Effects on Living Organisms
Biomedicines, 2021 Zinc is a redox-inert trace element that is second only to iron in abundance in biological systems. In cells, zinc is typically buffered and bound to metalloproteins, but it may also exist in a labile or chelatable (free ion) form.
Math P. Cuajungco +2 more
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Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
Nature Communications, 2017 NsrR is a bacterial transcriptional regulator that acts as a nitric oxide (NO) sensor. Here, the authors present the crystal structure of NsrR, which reveals an unusual Fe-S cluster coordination and explains how NO exposure leads to the degradation of ...
Anne Volbeda +7 more
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The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study
Frontiers in Chemistry, 2017 Erroneous activation of the Hedgehog pathway has been linked to a great amount of cancerous diseases and therefore a large number of studies aiming at its inhibition have been carried out. One leverage point for novel therapeutic strategies targeting the
Manuel Hitzenberger +3 more
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Decorin Is a Zn2+ Metalloprotein [PDF]
Journal of Biological Chemistry, 1999 Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang +4 more
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Magnetochemistry, 2023 In paramagnetic metalloproteins, longitudinal relaxation rates of 13C′ and 13Cα nuclei can be measured using 13C detected experiments and converted into electron spin-nuclear spin distance restraints, also known as Paramagnetic Relaxation Enhancement ...
Leonardo Querci +6 more
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Frontiers in Chemistry, 2021 The development of accurate and efficient potential energy functions for the molecular dynamics simulation of metalloproteins has long been a great challenge for the theoretical chemistry community.
Mingyuan Xu +6 more
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Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins
IUCrJ, 2019 An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein microcrystals using identical fixed-target supports at both synchrotrons and X-ray free-electron lasers
Ali Ebrahim +14 more
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