Results 61 to 70 of about 77,240 (295)

Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

Exploration, EarlyView.
BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood‐brain barrier for enhanced drug delivery.
Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan   +9 more
wiley   +1 more source

Comparison of RCAS1 and metallothionein expression and the presence and activity of immune cells in human ovarian and abdominal wall endometriomas

Reproductive Biology and Endocrinology, 2006
Background The coexistence of endometrial and immune cells during decidualization is preserved by the ability of endometrial cells to regulate the cytotoxic immune activity and their capability to be resistant to immune-mediated apoptosis.
Lazar Agata, Popiela Tadeusz, Banas Tomasz, Galazka Krystyna, Dutsch-Wicherek Magdalena, Wicherek Lukasz, Kleinrok-Podsiadlo Beata   +6 more
doaj   +1 more source

The role of zinc in renal pathological changes in diabetic status [PDF]

, 2015
Diabetes mellitus (DM) was the 8th leading cause of death in 2011, resulting in 1.4 million deaths worldwide. One of the complications of DM is chronic kidney disease, which accounts for nearly 44% of all new cases of kidney failure in the US in 2011 ...
Fernando, Julie, Zhou, Shaobo
core   +1 more source

Density and intensity of metallothionein of Crassostrea sp. as biomarkers of heavy metal contamination in the Northern coast of East Java, Indonesia

Egyptian Journal of Aquatic Research, 2021
The present study aimed to observe the expression level of metallothionein by analyzing its density and intensity in the gill and stomach of Crassostrea glomerata and Crassostrea iredalei.
Asus Maizar Suryanto Hertika, Kusriani Kusriani, Erlinda Indrayani, Renanda Baghaz Dzulhamdhani Surya Putra   +3 more
doaj  

Nuclear metallothionein in oral squamous cell carcinoma: clinicopathological parameters and patient survival

Brazilian Oral Research, 2018
The aim of this study was to identify the immunoexpression of methallothionein in oral squamous cell carcinoma as well as to address the correlation with clinical features, histological grade and patient survival.
Girlene Maria do Rego BEZERRA, Flávia Sirotheau Corrêa PONTES, Nicolau CONTE NETO, Liliane Silva do NASCIMENTO, Lucas Lacerda de SOUZA, Décio dos Santos PINTO JUNIOR, Hélder Antônio Rebelo PONTES   +6 more
doaj   +1 more source

Metallothioneins, a Part of the Retinal Endogenous Protective System in Various Ocular Diseases

Antioxidants, 2023
Metallothioneins are the metal-rich proteins that play important roles in metal homeostasis and detoxification. Moreover, these proteins protect cells against oxidative stress, inhibit proapoptotic mechanisms and enhance cell differentiation and survival.
Daniel Jamrozik, Radosław Dutczak, Joanna Machowicz, Alicja Wojtyniak, Adrian Smędowski, Marita Pietrucha-Dutczak   +5 more
doaj   +1 more source

Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs

PROTEOMICS, EarlyView.
ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou, Eleni M. Loizidou, George M. Spyrou   +2 more
wiley   +1 more source

Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities

Antioxidants, 2021
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH), affects 25% of the global population. Despite the prevalence of NAFLD worldwide, effective therapeutics are currently lacking. Amomum villosum var.
Jung-Hyo Cho, Jong-Suk Lee, Hyeong-Geug Kim, Hye Won Lee, Zhigang Fang, Hyeok-Hee Kwon, Dong Woon Kim, Chang-Min Lee, Jin-Woo Jeong   +8 more
doaj   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source

Metallothionein polymorphisms in pathological processes.

Metallomics, 2014
Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and
M. Raudenská, J. Gumulec, O. Podlaha, Markéta Sztalmachová, P. Babula, T. Eckschlager, V. Adam, R. Kizek, M. Masařík   +8 more
semanticscholar   +1 more source