Results 61 to 70 of about 75,382 (270)

Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.

Biological Research, 2004
Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease.
JUAN DIEGO MAYA, ANDRÉS RODRÍGUEZ, LAURA PINO, ADRIANA PABÓN, JORGE FERREIRA, MARIO PAVANI, YOLANDA REPETTO, ANTONIO MORELLO   +7 more
doaj  

On the nature of the Cu-rich aggregates in brain astrocytes

Redox Biology, 2017
Fulfilling a bevy of biological roles, copper is an essential metal for healthy brain function. Cu dyshomeostasis has been demonstrated to be involved in some neurological conditions including Menkes and Alzheimer's diseases.
Brendan Sullivan, Gregory Robison, Jenna Osborn, Martin Kay, Peter Thompson, Katherine Davis, Taisiya Zakharova, Olga Antipova, Yulia Pushkar   +8 more
doaj   +1 more source

Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism [PDF]

, 2023
Alicia Navarro‐Sempere, Pascual Martínez-Peinado, Armindo Rodrigues, Patrícia Garcia, Ricardo Camarinho, Guillermo Grindlay, Luis Gras, Magdalena Garcı́a, Yolanda Segovia   +8 more
openalex   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Animals, 2018
The aim of this study was to evaluate whether zinc (Zn) supplementation protects against hepatic copper (Cu) accumulation in copper-loaded sheep. Forty cross-bred lambs were assigned to five experimental groups.
Antonio Humberto Hamad Minervino, Marta López-Alonso, Raimundo Alves Barrêto Júnior, Frederico Augusto Mazzocca Lopes Rodrigues, Carolina Akiko Sato Cabral Araújo, Rejane Santos Sousa, Clara Satsuk Mori, Marta Miranda, Francisco Leonardo Costa Oliveira, Alexandre Coutinho Antonelli, Enrico Lippi Ortolani   +10 more
doaj   +1 more source

Organic and Inorganic Pollutants, Oxidative Stress Biomarkers, and Electrophoretic Protein Profiles in an Endangered Thresher Shark (Alopias vulpinus) From Southeastern Brazil: A Case Study

Environmental Toxicology, EarlyView.
ABSTRACT A comprehensive screening of different environmental contaminants (total metals, thermostable metal fractions associated with detoxification, and persistent organic pollutants) was conducted in an endangered common thresher shark (Alopias vulpinus ) individual incidentally captured in southeastern Brazil.
Sidney Fernandes Sales Junior, Amanda Pontes Lopes, Heloíse Martins de Souza, Regina Fonseca, Enrico Mendes Saggioro, Francielli Monteiro Casanova, Kamila Cezar Gramlich, Tatiana Dillenburg Saint'Pierre, Carlos German Massone, Renato Carreira, Rachel Ann Hauser‐Davis   +10 more
wiley   +1 more source

AzuR From the SmtB/ArsR Family of Transcriptional Repressors Regulates Metallothionein in Anabaena sp. Strain PCC 7120

Frontiers in Microbiology, 2022
Metallothioneins (MTs) are cysteine-rich, metal-sequestering cytosolic proteins that play a key role in maintaining metal homeostasis and detoxification.
T. V. Divya, T. V. Divya, Celin Acharya, Celin Acharya   +3 more
doaj   +1 more source

Cadmium in newborns [PDF]

, 2003
Cadmium (Cd) is a well-known nephrotoxic environmental contaminant but there are indications that the developing nervous system might be even more sensitive to Cd than the kidneys in adults.
Eklund, Gunilla
core  

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, EarlyView.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

Trace Element Analysis in Human Neuroblastoma Cell Spheroids Supplemented With ZnCl2 by Micro‐XRF

X-Ray Spectrometry, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhood, is responsible for ~10% of pediatric cancer deaths and has high potential for metastasis. Metals are extremely important in biological processes, and changes in their levels have been correlated with the development of cancerous growth.
J. E. P. Rosa, R. G. Leitão, G. C. Ferreira, C. Palmero, E. G. Oliveira‐Barros, M. A. Oliveira, C. G. L. Canellas, L. E. Nasciutti, D. F. Olivera, R. T. Lopes, M. J. Anjos   +10 more
wiley   +1 more source