Results 61 to 70 of about 30,614 (220)

Analysis of metallothionein gene structure in sterlet (Acipenser ruthenus) during copper exposure

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2017
Aquatic organisms present, not only simple sources of accumulated metal, but can interact with metals, altering their toxicity. Due to exposition of biosphere with metals, organisms have developed various defense mechanisms to protect themselves against ...
A Hadian; Sh Jamili email ; M Pourkazemi; A Mashinchian; M Yarmohammadi
doaj  

Expression of Drug-Resistant Factor Genes in Hepatocellular Carcinoma Patients Undergoing Chemotherapy with Platinum Complex by Arterial Infusion

Pharmaceutics, 2010
This study investigated gene expression of drug resistance factors in biopsy tissue samples from hepatocellular carcinoma (HCC) patients undergoing chemotherapy by platinum complex. Liver biopsy was performed to collect tissue from the tumor site (T) and
Shiro Ueda, Osamu Yokosuka, Masaharu Yoshikawa, Masahiko Sunaga, Eriko Kobayashi, Nobunori Satoh, Tomoya Sakurada   +6 more
doaj   +1 more source

Zinc Supplementation Forms Influenced Zinc Absorption and Accumulation in Piglets

Animals, 2020
The study aimed at determining the effect of different zinc (Zn) supplementation forms on Zn accumulation, activities of Zn-containing enzymes, gene expression of metallothionein (MT), and Zn transporters in piglets.
Fen-Fen Liu, Md. Abul Kalam Azad, Zhi-He Li, Jing Li, Kai-Bin Mo, Heng-Jia Ni   +5 more
doaj   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source

Metallothioneins in Arctic Bivalves

Ecotoxicology and Environmental Safety, 1998
In the framework of an International Association for the Promotion of Cooperation with Scientists from the Independent States of the Former Soviet Union (INTAS) Project on biodiversity and adaptation strategies of Arctic coastal marine benthos, research was focused on the role of metallothioneins as a possible indicator of the effect on animals and ...
Claude Amiard-Triquet, F. Rainglet, Herman Hummel, C. Larroux, Francesco Regoli   +4 more
openaire   +4 more sources

ZIP10 as a potential therapeutic target in acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Increased intracellular zinc levels in acute myeloid leukaemia blasts with upregulated expression of zinc influx transporters ZIP6 and ZIP10. Targeting ZIP10 with a surface antibody represents a potential therapeutic strategy. Created in BioRender. Rolles, B. (2025) https://BioRender.com/bwrtof1.
Benjamin Rolles, Nicolas Chatain, Richard Görg, Margherita Vieri, Nora Tillmann‐Tröster, Marcel G. Bourgeois, Deborah Christen, Jeanette Walter, Addison C. Hillerbrand, Kyle A. Romine, Kathryn M. Taylor, Jens Bertram, Edgar Jost, Steffen Koschmieder, Fabian Beier, Maximilian Stahl, Tim H. Brümmendorf, Lothar Rink, Inga Wessels   +18 more
wiley   +1 more source

The Alchemist’s Approach to Metal Poisoning: Transforming the Metal Burden

Toxics, 2014
Metal poisoning is a global problem with humans being exposed to a wide range of metals in varying doses and varying time frames. Traditionally, treatment involves removal of the toxic source or chelation therapy. An intermediate approach is needed. This
Wayne Briner
doaj   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Immunology, EarlyView.
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley   +1 more source

Cellular responses to thermal stress and moderate oxygen limitation in juvenile lake trout

Journal of Fish Biology, EarlyView.
Abstract Lake trout (Salvelinus namaycush) is an important food fish in northern communities, inhabiting cool, well‐oxygenated water, but climate change is reducing available habitat, with extended summer stratification of lakes creating an upper thermal barrier (~15°C) and lower dissolved oxygen (DO) boundary (4–7 mg L−1).
Alyssa M. Weinrauch, Analisa Lazaro‐Côté, Travis C. Durhack, Eva C. Enders, Ken M. Jeffries   +4 more
wiley   +1 more source