Results 51 to 60 of about 45,778 (231)

Algal Metallothioneins: Synthesis and regulation of two putative metallothioneins within the blue-green cyanobacteria anacystis nidulans [PDF]

open access: yes, 1989
Metallothioneins are low molecular-weight, cysteine-rich, trace metal-binding proteins. Whereas class III metallothioneins (MTs) have been isolated in eukaryotic algae, Anacystis nidulans (Synechococcus TX20) remains the only prokaryote in which a class ...
Marshall, Ross
core  

DNA Methylation and Detoxification in the Earthworm Lumbricus terrestris Exposed to Cadmium and the DNA Demethylation Agent 5-aza-2′-deoxycytidine

open access: yesToxics, 2022
Earthworms are well-established model organisms for testing the effects of heavy metal pollution. How DNA methylation affects cadmium (Cd) detoxification processes such as the expression of metallothionein 2 (MT2), however, is largely unknown.
Gerhard P. Aigner   +4 more
doaj   +1 more source

Dynamic structure of metallothionein [PDF]

open access: yes, 1984
Molecular sieve chromatography of rabbit liver metallothionein at different electrolyte concentrations revealed that this protein undergoes an increase in Stokes radius from 1.50 to 1.78 nm when the ionic strength is lowered from 0.5 to 0.015 indicating ...
Vašák, Milan   +5 more
core   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li   +3 more
wiley   +1 more source

Two metallothionein gene family members in buckwheat: Expression analysis in flooding stress using Real Time RT-PCR technology [PDF]

open access: yesArchives of Biological Sciences, 2008
Metallothioneins (MTs) are an extensive and diverse family of small cysteine-rich proteins with metal-binding ability that are involved in metal homeostasis and detoxification. Two cDNA clones of the MT3 type, differing in 3’ UTRs, were isolated from the
Majić Dragana B.   +4 more
doaj   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

open access: yesMed Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei   +9 more
wiley   +1 more source

The Alchemist’s Approach to Metal Poisoning: Transforming the Metal Burden

open access: yesToxics, 2014
Metal poisoning is a global problem with humans being exposed to a wide range of metals in varying doses and varying time frames. Traditionally, treatment involves removal of the toxic source or chelation therapy. An intermediate approach is needed. This
Wayne Briner
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman   +6 more
wiley   +1 more source

Detection of Metallothionein in Javanese Medaka (Oryzias javanicus), Using a scFv-Immobilized Protein Chip

open access: yesSensors, 2018
Environmental pollution by various industrial chemicals and biological agents poses serious risks to human health. Especially, marine contamination by potentially toxic elements (PTEs) has become a global concern in recent years.
Euiyeon Lee   +5 more
doaj   +1 more source

Effects of Waterborne Cadmium Exposure on Its Internal Distribution in Meretrix meretrix and Detoxification by Metallothionein and Antioxidant Enzymes

open access: yesFrontiers in Marine Science, 2020
Cadmium (Cd), one of the most toxic metals found in inshore sediments of China, is a persistent environmental contaminant capable of exerting irreversible toxic effects on aquatic organisms and their associated ecosystems.
Yao Huang   +5 more
doaj   +1 more source

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