Results 31 to 40 of about 982,999 (295)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Formation of Structure and Properties in Casting Processes on the Example of AZ91 Magnesium Alloy
Archives of Foundry Engineering, 2014 Contemporary materials engineering requires the use of materials characterised by high mechanical properties, as these precisely properties determine the choice of material for parts of machinery and equipment. Owing to these properties it is possible to
Augustyn B. +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Crystallographic Orientation, Recrystallization, and Texture Development in AZ91 Magnesium Alloy Rods Fabricated by Continuous Rotary Extrusion (CRE) [PDF]
Archives of Metallurgy and MaterialsThe magnesium alloy AZ91 is widely used in the aviation and automotive industries, where high mechanical properties combined with low density are required. Searching for new, advanced deformation methods in these industries is also essential.
M. Mitka +5 more
doaj +1 more source
Metal–metal bonds in biology [PDF]
Journal of Inorganic Biochemistry, 2012 Nickel-containing carbon monoxide dehydrogenases, acetyl-CoA synthases, nickel-iron hydrogenases, and diron hydrogenases are distinct metalloenzymes yet they share a number of important characteristics. All are O(2)-sensitive, with active-sites composed of iron and/or nickel ions coordinated primarily by sulfur ligands.
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Cailiao gongcheng, 2019 The hot compression test of the new ultra strength Al-Zn-Mg-Cu-Zr-Sc alloy at high temperature was carried out by using the Gleeble-1500 thermal simulator.
WANG Yu +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Effect of Dispersion Phases of SiC and Al2O3 on the Properties of Galvanic Nickel Coatings
Archives of Metallurgy and Materials, 2016 In this study, Ni, Ni-SiC and Ni-Al2O3 coatings were electroplated on the 2xxx series aluminium alloy. The following parameters of the electroplating process were applied: current density - 4A/dm2, time - 60 minutes, and temperature - 60°C.
Kozik A. +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source