Results 51 to 60 of about 829,330 (310)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Effect of Extrusion Parameters on Possibility of Extrusion of Magnesium Alloys in Continuous Rotary Extrusion Process / Wpływ Parametrów Procesu Wyciskania Na Możliwość Wyciskania Stopów Magnezu Metodą Ciągłego Wyciskania Na Kole

Archives of Metallurgy and Materials, 2015
Continuous rotary extrusion (CRE) is the more and more frequently used variation of the plastic working process. Magnesium alloys, due to its properties are becoming increasingly popular as a substitute for aluminium alloys and steel, particularly in the
Mitka M., Gawlik M., Bigaj M., Szymański W.   +3 more
doaj   +1 more source

Metallic hydrogen [PDF]

Journal of Physics: Condensed Matter, 2018
Abstract Hydrogen is the simplest and most abundant element in the Universe. There are two pathways for creating metallic hydrogen under high pressures. Over 80 years ago Wigner and Huntington predicted that if solid molecular hydrogen was sufficiently compressed in the T   =
Ranga Dias, Isaac Silvera
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Ventilation and air conditioning design approach based on ASHRAE psychrometric chart and Mollier diagram

Frontiers in Built Environment
Society needs long-term sustainability and healthy building projects, and indoor air quality assurance engineering systems play a pivotal role in the energy performance of buildings.
Arturs Lešinskis, Uldis Strauts, Mārtiņš Metāls, Renārs Millers, Viktors Afoņičevs   +4 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Studies of the AA2519 Alloy Hot Rolling Process and Cladding with EN AW-1050A Alloy

Archives of Metallurgy and Materials, 2016
The objective of the study was to determine the feasibility of plastic forming by hot rolling of the AA2519 aluminium alloy sheets and cladding these sheets with a layer of the EN AW-1050A alloy.
Płonka B., Rajda M., Zamkotowicz Z., Żelechowski J., Remsak K., Korczak P., Szymański W., Snieżek L.   +7 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Fabrication and mechanical properties of porous tantalum carbon composites by chemical vapor deposition

Scientific Reports
This study investigates the deposition of tantalum (Ta) coatings on carbon foams using the chemical vapor deposition (CVD) method to enhance their compressive strength.
Junyu Zhu, Wenting Li, Hongzhong Cai, Xian Wang, Xingqiang Wang, Wuxun Zhu, Yan Wei, Xuming Li, Xingdong Zhao, Guixue Zhang, Haohong Jiang   +10 more
doaj   +1 more source