Results 71 to 80 of about 2,983,736 (353)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Studies of the AA2519 Alloy Hot Rolling Process and Cladding with EN AW-1050A Alloy

Archives of Metallurgy and Materials, 2016
The objective of the study was to determine the feasibility of plastic forming by hot rolling of the AA2519 aluminium alloy sheets and cladding these sheets with a layer of the EN AW-1050A alloy.
Płonka B., Rajda M., Zamkotowicz Z., Żelechowski J., Remsak K., Korczak P., Szymański W., Snieżek L.   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fabrication and mechanical properties of porous tantalum carbon composites by chemical vapor deposition

Scientific Reports
This study investigates the deposition of tantalum (Ta) coatings on carbon foams using the chemical vapor deposition (CVD) method to enhance their compressive strength.
Junyu Zhu, Wenting Li, Hongzhong Cai, Xian Wang, Xingqiang Wang, Wuxun Zhu, Yan Wei, Xuming Li, Xingdong Zhao, Guixue Zhang, Haohong Jiang   +10 more
doaj   +1 more source

Synthesis and inclusion behavior of a heterotritopic receptor based on hexahomotrioxacalix[3]arene [PDF]

, 2014
A heterotritopic hexahomotrioxacalix[3]arene receptor with the capability of binding two alkali metals and a transition metal in a cooperative fashion was synthesized.
Cong, Hang, Jin, Cheng-Cheng, Ni, Xin-Long, Redshaw, Carl, Yamato, Takehiko, Zeng, Xi   +5 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Effect of Aging Parameters of EN AW-7021 Aluminium Alloys on Stress Corrosion Cracking [PDF]

Archives of Metallurgy and Materials
The main assumption of the conducted research was the selection of appropriate heat treatment parameters to obtain the best possible resistance to stress corrosion cracking (SCC) and the highest strength properties of the extruded profiles.
S. Boczkal, M. Węgrzyn, W. Szymański, J. Bem, K. Wala, B. Płonka, D. Leśniak, M. Nowak   +7 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Texture and mechanical properties of cold-rolled Ti-26Nb-4Zr alloy plates

工程科学学报, 2015
The effects of cold rolling and solution treatment on the texture and mechanical properties of Ti-26Nb-4Zr alloy plates were investigated by X-ray diffraction and tensile testing at room temperature.
SONG Xiao-yun, YE Wen-jun, WANG Yan-ling, CHEN Zhi-lin, HUI Song-xiao   +4 more
doaj   +1 more source