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Use of a complex approach for assessment of metamizole sodium and acetylsalicylic acid toxicity, genotoxicity and cytotoxicity

Journal of Applied Toxicology, 2004
AbstractA complex approach based on the use of test organisms belonging to different systematic groups (plants, invertebrates and vertebrates), as well as the nucleolar biomarker and the micronucleus test on their cells, was applied to assess the toxicity, cytotoxicity and genotoxicity of two pharmaceutical substances (metamizole sodium and ...
V V, Arkhipchuk   +4 more
exaly   +3 more sources

Stability and Determination of Metamizole Sodium by Capillary Electrophoresis Analysis Combined with Infra-red Spectroscopy

Chemical Research in Chinese Universities, 2007
Abstract Metamizole sodium was chosen as a representative of unstable analytes for investigation by discussing the effects of oxygen and solvent on its degradation reaction using the capillary electrophoresis technique. A possible degradation mechanism was deduced from the observed behavior and was confirmed by infra-red spectroscopic study.
Q XIANG, G NIU, X WU, G CHEN
exaly   +2 more sources

Titrimetric semi-micro determination of sodium metamizole with Potassium hydrogenperoxymonosulphate

Pharmakeftiki
A simple, rapid and accurate titrimetric procedure using potassium hydrogenperoxymonosulphate have been developed for the semi-micro determination of sodium metamizole in pure form and in tablets. The proposed method is based on the oxidation of bisulfite ions formed as a result of acid hydrolysis of sodium metamizole by known excess of the potassium ...
Koretnik, Oksana, Blazheyevskiy, Mykola
openaire   +1 more source

Dissolution studies of metamizole sodium and pseudoephedrine sulphate dosage forms − comparison and correlation of electronic tongue results with reference studies

Journal of Pharmaceutical and Biomedical Analysis, 2018
This work reports a critical evaluation of the results of the release of active substances (APIs) from novel pharmaceutical formulations provided by an electronic tongue system (ET). Detailed dissolution studies of modified-release granules used in pharmacotherapy containing metamizole sodium and pseudoephedrine sulphate were carried out. The impact of
Małgorzata, Wesoły   +4 more
openaire   +2 more sources

Metamizole sodium may induce neural tube defects in a chick embryo model

2014
65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Guvenc, Y   +7 more
openaire   +2 more sources

Efficacy and safety of metamizole sodium for pain syndrome in adults and children: a systematic review

Russian Journal of Pain
Objective. To conduct a systematic review of data on efficacy and safety of metamizole sodium (MS) for pain syndrome in adults and children. Material and methods. A systematic review was conducted. At the first stage, we reviewed available databases regarding efficacy and safety of MS for pain syndrome in adults and children compared to other ...
M.L. Kukushkin   +6 more
openaire   +1 more source

The Effect of Paracetamol, Metamizole Sodium and Ketoprofen on Postoperative Hemorrhage Following Pediatric Tonsillectomy

Journal of Otology & Rhinology, 2014
The Effect of Paracetamol, Metamizole Sodium and Ketoprofen on Postoperative Hemorrhage Following Pediatric Tonsillectomy Aim: The aim of the present study was to determine the association between postoperative hemorrhage and using paracetamol, metamizole sodium and ketoprofen as analgesics after pediatric tonsillectomy.
openaire   +1 more source

[Determination of content of chlorpromazine hydrochloride in compound metamizole sodium microenema by acid-dye colorimetric method].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1998
An acid-dye colormetric method was described for the determination of chlorpromazine hydrochloride in the compound preparation. The method was based on the reaction of chlorpromazine hydrochloride with methyl orange, to form a yellow complex, which then was extracted by chloroform and exhibited a maximum absorption at 424 nm. The optimal conditions for
Z, Zhou, L, Wang, Y, Peng, X, Zhang
openaire   +1 more source

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

Polish Journal of Surgery, 2008
Adam Srebrzyński   +5 more
openaire   +1 more source

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