Evaluating the analgesic effect of metamizole in the mouse model for DSS-induced acute colitis [PDF]
Frontiers in PhysiologyA commonly used mouse model of ulcerative colitis is the Dextran Sodium Sulphate (DSS) colitis model, including symptoms of weight loss, softening of stool up to diarrhea, and abdominal pain.
D. T. Jacob +12 more
doaj +3 more sources
Metamizole-induced agranulocytosis from a German intensive care perspective [PDF]
Frontiers in MedicineBackground/objectivesMetamizole (dipyrone) is a non-opioid analgesic and antipyretic widely used in Germany, with prescriptions having increased more than tenfold since 1997.
Laura Hille +5 more
doaj +3 more sources
Assessing potential risk factors for metamizole-induced leukopenia
Therapeutic Advances in Drug SafetyBackground: Metamizole is a non-opioid analgesic agent that can rarely cause agranulocytosis, a severe form of leukopenia. Objectives: The aim of this study was to assess previously identified potential risk factors for the development of metamizole ...
Jörg Leuppi, Anne Leuppi-Taegtmeyer
exaly +3 more sources
A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]
Scientific ReportsMetamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi +7 more
doaj +2 more sources
The effect of scheduled metamizole on opioid consumption after cardiac surgery [PDF]
Frontiers in PharmacologyThis retrospective study evaluates the impact of implementing a standardized scheduled metamizole dosing protocol within a multimodal analgesia approach after cardiac surgery.
Chen Seidenberg +7 more
doaj +2 more sources
Metamizole does not affect fracture healing in a murine ischemia model [PDF]
Frontiers in PhysiologyMetamizole is a commonly used analgesic drug in clinical fracture management, which does not affect the healing process under physiological conditions.
Christian Schönbeck +13 more
doaj +2 more sources
Risk Factors for Intolerable Postoperative Pain After Vitreoretinal Surgery Under AoA-Guided General Anesthesia with Intravenous COX-3 Inhibitors: A Post Hoc Analysis [PDF]
PharmaceuticalsBackground/Objectives: Intolerable postoperative pain perception (IPPP) may occur in patients undergoing vitreoretinal surgery (VRS), while general anesthesia (GA) is often preferred over regional techniques due to multiple contraindications ...
Michał J. Stasiowski +3 more
doaj +2 more sources
Clinical Characteristics and Prognostic Factors of Patients with Acute Poisoning: A Retrospective Observational Cohort Study of Diquat, Single-Drug and Mixed-Drug Exposures [PDF]
Risk Management and Healthcare PolicyHongyu Han,1,* Lihua Gao,2,* Han Cui,1 Dan Li,3 Yanan Hou,4 Jing Jiang,5 Hongna Sun11Poisoning Intensive Care Unit, 982nd Hospital of the Chinese People’s Liberation Army Joint Logistics Support Force, Tangshan City, Hebei Province ...
Han H +6 more
doaj +2 more sources
Proliferative effects of metamizole sodium on U-87 MG glioblastoma cell line: a pain killer or a killer? [PDF]
World Cancer Research Journal, 2021 OBJECTIVE: During cancer treatment, painkillers are often used to alleviate patient pain. Metamizole is a pyrazolone derivative and a non-opioid pain reliever.
O. Koçak, E. Şimşek
doaj +1 more source
Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
Drugs in R&D, 2023 Background and objective Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole.
Raphael Allgaier +5 more
doaj +1 more source