Metamizole (dipyrone) – cytotoxic and antiproliferative effects on HeLa, HT-29 and MCF-7 cancer cell lines [PDF]
Biotechnology & Biotechnological Equipment, 2018 Cancer pain treatment is a big challenge for healthcare providers and patients as well. The wide range of non-steroidal anti-inflammatory drugs (NSAIDs) used as painkillers in cancer patients, requires in-depth characterization of their effect on the ...
Irina Nikolova +6 more
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Ventral posteromedial nucleus of the thalamus as a neuroanatomical target for the anticephalalgic action of valproic acid and metamizole [PDF]
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Introduction. Valproic acid and metamizole are widely used in the treatment of primary headaches. However, despite the drugs’ proven clinical efficacy, the neurophysiological mechanisms underlying their therapeutic action are poorly understood.
A. Yu. Sokolov, O. A. Lyubashina
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Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis [PDF]
Animals, 2020 Pain management during in vivo experiments is an animal welfare concern and is in many countries also legally required. In this study, we evaluated C57Bl/6J mice when 3 g/L metamizole or 1 g/L tramadol was provided via drinking water, before and during ...
Guanglin Tang +4 more
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A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]
Scientific ReportsMetamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi +7 more
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Metamizole-induced agranulocytosis from a German intensive care perspective [PDF]
Frontiers in MedicineBackground/objectivesMetamizole (dipyrone) is a non-opioid analgesic and antipyretic widely used in Germany, with prescriptions having increased more than tenfold since 1997.
Laura Hille +5 more
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PLoS ONE, 2020 BACKGROUND:Normothermic ex vivo liver perfusion (NEVLP) is a promising strategy to increase the donor pool in liver transplantation. Small animal models are essential to further investigate questions regarding organ preservation and reconditioning by ...
Felix Claussen +12 more
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The effect of scheduled metamizole on opioid consumption after cardiac surgery [PDF]
Frontiers in PharmacologyThis retrospective study evaluates the impact of implementing a standardized scheduled metamizole dosing protocol within a multimodal analgesia approach after cardiac surgery.
Chen Seidenberg +7 more
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Acute Liver Failure in a Patient Treated With Metamizole
Frontiers in Pharmacology, 2019 We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes.
Philipp Krisai +2 more
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Noramidopyrine (Metamizol) and acute interstitial nephritis [PDF]
Nephrology Dialysis Transplantation, 1998 amount ingested: 30 g). On admission his serum creatiIntroduction nine and blood urea nitrogen (BUN) were 4.5 mg/dl and 39 mg/dl respectively. Urinalysis revealed 30 mg/dl Noramidopyrine (Metamizol ) is a non-narcotic, protein, 3+ positive for blood (dipstick), and 5–10 analgesic and antipiretic pyrazolone derivative which red blood cells and 3–5 white
V. Berruti +6 more
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Metamizole does not affect fracture healing in a murine ischemia model [PDF]
Frontiers in PhysiologyMetamizole is a commonly used analgesic drug in clinical fracture management, which does not affect the healing process under physiological conditions.
Christian Schönbeck +13 more
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